SPARC (Secreted Protein Acidic And Cysteine Rich)

Here, we evaluated cDNA microarray data from a previous study from our group to investigate the effects of SPARC expression on the transcriptome of MCF7 cells before and after treatment with docetaxel...Of these 9 DELncRNAs, MIR155HG, LOC283856, LOC100190986, and KIAA0125 were significantly correlated with recurrence-free survival and overall survival rates of BC patients, suggesting they could help predict the outcome of BC patients as prognostic factors. Moreover, in silico analysis showed that these DELncRNAs were able to predict BC patients' responses to different treatment protocols.

qPCR analysis revealed that the significant expressions of SPARC, EFEMP1, RGS5 and SERPINE1 were significantly upregulated in gastric cancer tissues compared to the normal tissues. Our study provides insights into the composition of the tumor microenvironment and construction of a four-gene CAF signature associated with clinical prognosis, offering new perspectives for the clinical management of gastric cancer.

Our findings suggest that the expression levels of serglycin, ILK, ESD, and PLPD1 may play a significant role in the development of LAC. This information can be valuable for identifying potential treatment targets for lung cancer.

Albumin enables selective delivery of doxorubicin (DOX) and chlorin e6 (Ce6) via SPARC-receptor interactions, while oxygen vacancy-engineered cerium oxide (CeO2) decomposes endogenous hydrogen peroxide to generate oxygen, alleviating hypoxia...Mechanistic analyses reveal activation of autophagy and pyroptosis, suppression of oncogenic signaling, and upregulation of tumor suppressor genes. This clinically informed nanoplatform establishes a versatile therapeutic paradigm that translates patient tissue-derived molecular features into precise, multimodal strategies for overcoming hypoxia-associated, treatment-refractory cancers.

Adjuvant chemotherapy improves survivals in sSPARC+ pancreatic cancer patients, indicating suggesting sSPARC expression as a prognostic biomarker and potential indicator for neoadjuvant treatment planning.

In parallel, ECM remodeling was evident, with increased expression of SPARC and FN1 and collagen fiber alignment, reflecting an invasive tumor phenotype. This scaffold-free 3D HCC model recapitulates key physiopathological features of tumor progression, providing a robust and physiologically relevant platform to investigate the hypoxia-ROS-ECM relationship and to support preclinical evaluation of targeted therapeutic strategies.

Indeed, we found that miR-29b1~a expression is inversely correlated with SPARC levels, and it is significantly reduced in samples with a mesenchymal-like phenotype. Taken together, SPARC expression in melanoma cells relies on transcriptional activation by PRRX1/TCF7L2-Sp1 and is modulated through miR-29b1~a, which provides fine-tuning regulation over the switch between phenotypic states.

Sparc may maintain mitochondrial homeostasis by interacting with Uba52 to inhibit LPS-induced BV2 inflammatory response, thereby promoting neuronal axonal regeneration. This suggests that Sparc may play a potential role in SCI repair.

By promoting ferroptosis and reestablishing cellular sensitivity to radiation, these radiosensitizers significantly enhance the response of cancer cells to radiotherapy. Our findings underscore the potential of integrating ferroptosis targeting with radiosensitization as an efficient strategy to enhance antitumor efficacy of radiotherapy, offering a promising avenue to overcome radioresistance in clinical settings.

A program of RT or HIIT can increase levels of myokines (an effect considered beneficial given their potential cancer-suppressive effects) and inhibit growth of MDA-MB-231 cells in survivors of breast cancer. In addition, development of the anti-tumor environment may be mediated by exercise-related changes in muscle strength and body composition.

BDSSPArcis a novel gantry velocity scheduling algorithm for SPArc treatment delivery that enhances the delivery efficiency and generates smoother velocity profiles compared with DSMSPArc, offering a practical and optimized ingredient in SPArc planning.