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BIOMARKER:

SPARC overexpression

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Other names: SPARC, Secreted Protein Acidic And Cysteine Rich, BM-40, Secreted Protein Acidic And Rich In Cysteine, Basement-Membrane Protein 40, Osteonectin, SPARC, ONT, ON, Secreted Protein, Acidic, Cysteine-Rich (Osteonectin), Cysteine-Rich Protein, OI17
Entrez ID:
Related biomarkers:
1m
MiR-211-5p Inhibits the Biological Behaviors of Colorectal Cancer via SPARC-Related Growth Factor Pathways. (PubMed, J Cancer)
Finally, SPARC overexpression suppressed the inhibitory effect of miR-211-5p on CRC cell progression. MiR-211-5p suppressed the invasion, migration, proliferation, and progression of CRC cells through sponging SPARC-related growth factor pathways.
Journal
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SPARC (Secreted Protein Acidic And Cysteine Rich) • TGFB1 (Transforming Growth Factor Beta 1) • MIR211 (MicroRNA 211)
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SPARC overexpression • miR-211 expression
1m
Methylation-mediated expression of SPARC is correlated with tumor progression and poor prognosis of breast cancer. (PubMed, Neoplasma)
Conversely, the expression levels of EMT-related genes demonstrated the opposite trend in SPARC knockdown cells. To conclude, high expression of SPARC regulated by promoter hypomethylation promotes breast cancer cells migration and invasion, thus SPARC may act as an oncogene and serve as a potential target for breast cancer therapy.
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CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CDH1 (Cadherin 1) • SPARC (Secreted Protein Acidic And Cysteine Rich) • VIM (Vimentin) • CDH2 (Cadherin 2)
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SPARC overexpression • VIM expression
3ms
Activation of the PI3K-AKT signaling pathway by SPARC contributes to the malignant phenotype of cholangiocarcinoma cells. (PubMed, Tissue Cell)
Mechanically, SPARC promoted proliferation, migration, invasion, and EMT of CCA cells in vitro via activating the PI3K-AKT signaling. Overall, our integrated analysis revealed that SPARC plays a crucial role in CCA progression via the PI3K-AKT signaling pathway, which suggests that targeting SPARC might represent a promising approach for improving CCA patient's clinical outcome.
Journal
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SPARC (Secreted Protein Acidic And Cysteine Rich)
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SPARC overexpression
5ms
SPARC Overexpression Promotes Liver Cancer Cell Proliferation and Tumor Growth. (PubMed, Front Mol Biosci)
However, in sorafenib-treated LIHC patients, the high SPARC expression predicts favorable prognosis... SPARC mRNAs were increased in LIHC tumor tissues, and SPARC overexpression may promote the liver cancer growth. Further studies are needed to clarify the potential prognostic value of SPARC, both in tissues and in circulation.
Journal
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SPARC (Secreted Protein Acidic And Cysteine Rich)
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SPARC overexpression
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Nexavar (sorafenib)
7ms
Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells. (PubMed, Evid Based Complement Alternat Med)
Overexpression of SPARC vectors promoted cancer cell development. SPARC affected the patient's disease development by regulating the biological behavior of the MM cells.
Journal
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SPARC (Secreted Protein Acidic And Cysteine Rich)
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SPARC overexpression
9ms
Diagnostic and prognostic value of secreted protein acidic and rich in cysteine in the diffuse large B-cell lymphoma. (PubMed, World J Clin Cases)
SPARC was highly expressed in DLBCL, and the overexpression of SPARC showed sound diagnostic value. More interestingly, the overexpression of SPARC might be a favorable prognostic biomarker for DLBCL, suggesting that SPARC might be an inducible factor in the development of DLBCL, and inducible SPARC was negative in some oncogenic pathways. All the evidence suggested that inducible SPARC might be a good diagnostic and prognostic biomarker for DLBCL.
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KRAS (KRAS proto-oncogene GTPase) • SPARC (Secreted Protein Acidic And Cysteine Rich)
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SPARC overexpression