Other names: SPARC, Secreted Protein Acidic And Cysteine Rich, BM-40, Secreted Protein Acidic And Rich In Cysteine, Basement-Membrane Protein 40, Osteonectin, SPARC, ONT, ON, Secreted Protein, Acidic, Cysteine-Rich (Osteonectin), Cysteine-Rich Protein, OI17
Finally, SPARC overexpression suppressed the inhibitory effect of miR-211-5p on CRC cell progression. MiR-211-5p suppressed the invasion, migration, proliferation, and progression of CRC cells through sponging SPARC-related growth factor pathways.
1 month ago
SPARC (Secreted Protein Acidic And Cysteine Rich) • TGFB1 (Transforming Growth Factor Beta 1) • MIR211 (MicroRNA 211)
Conversely, the expression levels of EMT-related genes demonstrated the opposite trend in SPARC knockdown cells. To conclude, high expression of SPARC regulated by promoter hypomethylation promotes breast cancer cells migration and invasion, thus SPARC may act as an oncogene and serve as a potential target for breast cancer therapy.
1 month ago
CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CDH1 (Cadherin 1) • SPARC (Secreted Protein Acidic And Cysteine Rich) • VIM (Vimentin) • CDH2 (Cadherin 2)
Mechanically, SPARC promoted proliferation, migration, invasion, and EMT of CCA cells in vitro via activating the PI3K-AKT signaling. Overall, our integrated analysis revealed that SPARC plays a crucial role in CCA progression via the PI3K-AKT signaling pathway, which suggests that targeting SPARC might represent a promising approach for improving CCA patient's clinical outcome.
However, in sorafenib-treated LIHC patients, the high SPARC expression predicts favorable prognosis... SPARC mRNAs were increased in LIHC tumor tissues, and SPARC overexpression may promote the liver cancer growth. Further studies are needed to clarify the potential prognostic value of SPARC, both in tissues and in circulation.
SPARC was highly expressed in DLBCL, and the overexpression of SPARC showed sound diagnostic value. More interestingly, the overexpression of SPARC might be a favorable prognostic biomarker for DLBCL, suggesting that SPARC might be an inducible factor in the development of DLBCL, and inducible SPARC was negative in some oncogenic pathways. All the evidence suggested that inducible SPARC might be a good diagnostic and prognostic biomarker for DLBCL.
9 months ago
KRAS (KRAS proto-oncogene GTPase) • SPARC (Secreted Protein Acidic And Cysteine Rich)