^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    SPAG1 (Sperm Associated Antigen 1)

    i
    Other names: SPAG1, Sperm Associated Antigen 1, HSD-3.8, DNAAF13, CILD28, CT140, SP75, TPIS, Infertility-Related Sperm Protein Spag-1, Dynein Axonemal Assembly Factor 13, Sperm-Associated Antigen 1, FLJ32920, TPR-Containing Protein Involved In Spermatogenesis, Tetratricopeptide Repeat-Containing Protein, Epididymis Secretory Protein Li 268, HEL-S-268
    Associations

    News

    Trials
    1m
    Dioxin, an endocrine disruptor, induces long term effects on DNA methylation in men after in-utero exposure. (PubMed, Minerva Endocrinol (Torino))
    These observations are the first in the literature and align with the long-term semen quality reduction and alteration of thyroid homeostasic mechanisms reported in children exposed in utero to dioxin in Seveso. The actual dioxin background serum levels, 1.0-2.0 ppt, are much lower than those associated to these effects.
    Journal
    |
    SPAG1 (Sperm Associated Antigen 1)
    2ms
    A cancer-testis antigen signature for predicting prognosis and response to immunotherapy in acute myeloid leukemia. (PubMed, Medicine (Baltimore))
    Drug sensitivity profiling highlighted differential therapeutic vulnerabilities between risk groups. This study established and validated a novel CTA-based prognostic tool for prognostic stratification and personalized treatment guidance in AML, bridging molecular insights with clinical applications.
    Journal • IO biomarker
    |
    ACRBP (Acrosin Binding Protein) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) • KDM5B (Lysine Demethylase 5B) • SPAG1 (Sperm Associated Antigen 1)
    almost2years
    RGIE: A Gene Selection Method Related to Radiotherapy Resistance in Head and Neck Squamous Cell Carcinoma. (PubMed, Curr Radiopharm)
    RGIE is effective in screening genes related to HNSCC-RR. This approach may help guide clinical treatment modalities for patients and develop potential treatments.
    Journal
    |
    TCF7L2 (Transcription Factor 7 Like 2) • SPAG1 (Sperm Associated Antigen 1)
    over2years
    Germline Genetic Variants and Pediatric Rhabdomyosarcoma Outcomes: A Report from the Children's Oncology Group. (PubMed, J Natl Cancer Inst)
    We demonstrated that common germline variants are associated with EFS and OS among individuals with RMS. Additional replication and investigation of these SNP effects may further support their consideration in risk stratification protocols.
    Journal
    |
    GATA2 (GATA Binding Protein 2) • GATA3 (GATA binding protein 3) • PAX3 (Paired Box 3) • SPAG1 (Sperm Associated Antigen 1)
    over3years
    SPAG1 promotes the development of AML by activating the ERK/MAPK signaling pathway and affects the chemotherapy sensitivity of venetoclax. (PubMed, Neoplasma)
    Furthermore, we discovered that inhibiting SPAG1 impacted AML cell susceptibility to venetoclax. In conclusion, SPAG1 may serve as a potential therapeutic target in AML.
    Journal
    |
    FLT3 (Fms-related tyrosine kinase 3) • SPAG1 (Sperm Associated Antigen 1)
    |
    FLT3 mutation
    |
    Venclexta (venetoclax)