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    GENE:

    SPA1L (Heat Shock Protein Family A (Hsp70) Member 1 Like)

    i
    Other names: SPA1L, Heat Shock Protein Family A (Hsp70) Member 1 Like, HSP70-HOM, Hum70t, Heat Shock 70 KDa Protein 1-Like, Heat Shock 70kDa Protein 1-Like, Heat Shock 70 KDa Protein 1-Hom, Heat Shock 70kD Protein-Like 1, Heat Shock 70 KDa Protein 1L, Epididymis Secretory Sperm Binding Protein, Heat Shock 10kDa Protein 1-Like, HSP70-Hom, HSP70-1L, HSP70T
    Associations

    News

    Trials
    2years
    Analyzing Interaction of Rhodacyanine Inhibitor 'MKT-077' with Plasmodium falciparum HSP70s. (PubMed, Drug Metab Bioanal Lett)
    Information obtained in this study may form the foundation for the design and de-velopment of MKT-077-based drugs against malaria.
    Journal
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    SPA1L (Heat Shock Protein Family A (Hsp70) Member 1 Like)
    over2years
    Secretome profiling of Artemisia absinthium extract-loaded polymeric nanoparticle-treated MCF-7 and MDA-MB-231 revealed perturbation in microtubule assembly and cell migration. (PubMed, Front Oncol)
    Correlation analysis between their mRNA expressions versus immune cell infiltrates showed a positive correlation with antitumor immune response elicited by these NPs as well as a correlation with drug response shown by the GDSC and CTRP drugs in different cancer cells. Our results suggest that NVA-AA NPs were able to invade the tumor microenvironment; transformed the communication network between the cancer cells; affected potential drivers of microtubular integrity, nucleosome assembly, and cell cycle; and eventually caused cell death.
    Journal
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    AFP (Alpha-fetoprotein) • TUBA1C (Tubulin Alpha 1c) • GSN (Gelsolin) • SPA1L (Heat Shock Protein Family A (Hsp70) Member 1 Like) • TUBA1B (Tubulin Alpha 1b)