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BIOMARKER:

SOX9 overexpression

i
Other names: SOX9, SRY-Box Transcription Factor 9, Transcription Factor SOX-9, SRY-Box 9, SRY (Sex-Determining Region Y)-Box 9 Protein, Campomelic Dysplasia Autosomal Sex-Reversal, SRY (Sex Determining Region Y)-Box 9, SRY (Sex Determining Region Y)-Box9, SRY-Related HMG-Box Gene 9, SRXY10, SRXX2, CMPD1, SRA1, CMD1
Entrez ID:
Related biomarkers:
29d
MFAP5 Strengthened the Stem Cell Features of Non-small Cell Lung Cancer Cells by Regulating the FBW/Sox9 Axis. (PubMed, Curr Pharm Biotechnol)
MFAP5 maintained the stem cell features of non-small cell lung cancer cells by modulating FBW7/Sox9 axis.
Journal
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FBXW7 (F-Box And WD Repeat Domain Containing 7) • SOX9 (SRY-Box Transcription Factor 9)
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SOX9 overexpression • SOX9 expression
2ms
Exposure of piperlongumine attenuates stemness and epithelial to mesenchymal transition phenotype with more potent anti-metastatic activity in SOX9 deficient human lung cancer cells. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)
This has been the first study to discover the high expression of SOX9 supporting the survival of LCC, whereas its inhibition induces higher sensitivity to PIP treatment. This study concludes a newer therapeutic agent (PIP) with promising anticancer activity against LCC by escalating ROS and attenuating MMP, stemness, and EMT.
Journal • Metastases
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SOX9 (SRY-Box Transcription Factor 9)
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SOX9 overexpression • SOX9 expression
2ms
Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9. (PubMed, Cancer Biol Ther)
Hypoxia induced the lactylation of SOX9 to promote stemness, migration, and invasion via promoting glycolysis. The findings suggested that targeting hypoxia may be an effective way for NSCLC treatment and reveal a new mechanism of hypoxia in NSCLC.
Journal
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SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
5ms
SOX9 promotes the invasion and migration of lung adenocarcinoma cells by activating the RAP1 signaling pathway. (PubMed, BMC Pulm Med)
Overexpression of SOX9 in LUAD can significantly activate the RAP1 signaling pathway and promote cell invasion and migration.
Journal
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SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
7ms
Upregulation of SOX9 promotes the self-renewal and tumorigenicity of cervical cancer through activating the Wnt/β-catenin signaling pathway. (PubMed, FASEB J)
In addition, SOX9 could transcriptional inhibit DKK1 and activate FZD10 and MYC by binding to their promoters to affect the Wnt/β-catenin pathway. These results demonstrated SOX9 regulated the self-renewal and tumorigenicity of cervical cancer through Wnt/β-catenin pathway by directly transcriptional activation of FZD10, MYC and transcriptional inhibition of DKK1.
Journal
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • DKK1 (dickkopf WNT signaling pathway inhibitor 1) • SOX9 (SRY-Box Transcription Factor 9) • FZD10 (Frizzled Class Receptor 10)
|
MYC expression • SOX9 overexpression • SOX9 expression
7ms
SOX9/NFIA promotes human ovarian cancer metastasis through the Wnt/β-catenin signaling pathway. (PubMed, Pathol Res Pract)
In conclusion, this study shows that SOX9 has a promotional effect on human ovarian cancer and that SOX9 promotes the metastasis of tumors by upregulating NFIA and activating on a Wnt/β-catenin signal pathway. SOX9 could be a novel focus for earlier diagnosis, therapy and prospective evaluation in ovarian cancer.
Journal
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CDH1 (Cadherin 1) • MUC16 (Mucin 16, Cell Surface Associated) • SOX2 • SOX9 (SRY-Box Transcription Factor 9) • CDH2 (Cadherin 2)
|
CDH1 expression • SOX9 overexpression • SOX9 expression
8ms
Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway. (PubMed, J Ovarian Res)
Taken together, our findings suggest that circ-PHC3 enhances OC progression through functioning as an miR-497-5p sponge to promote SOX9 expression, supporting its potential as a promising candidate target for OC therapy.
Journal
|
SOX9 (SRY-Box Transcription Factor 9) • MIR497 (MicroRNA 497)
|
SOX9 overexpression • SOX9 expression
12ms
Comprehensive analysis, immune, and cordycepin regulation for SOX9 expression in pan-cancers and the matched healthy tissues. (PubMed, Front Immunol)
Moreover, SOX9 might play an important role in tumor genesis and development by participating in immune infiltration. Altogether, SOX9 could be a biomarker for diagnostics and prognostics for pan-cancers and an emerging target for the development of anticancer drugs.
Journal • Pan tumor
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SOX9 (SRY-Box Transcription Factor 9) • YBX1 (Y-Box Binding Protein 1)
|
SOX9 overexpression • SOX9 expression
|
cordycepin (OVI-123)
1year
SOX9 and HMGB3 co-operatively transactivate NANOG and promote prostate cancer progression. (PubMed, Prostate)
These findings showed a novel SOX9/HMGB3/NANOG regulatory mechanism, deregulation of which played important roles in PCa progression.
Journal
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SOX9 (SRY-Box Transcription Factor 9) • NANOG (Nanog Homeobox)
|
SOX9 overexpression • SOX9 expression
over1year
Deubiquitylase OTUD1 confers Erlotinib sensitivity in non-small cell lung cancer through inhibition of nuclear translocation of YAP1. (PubMed, Cell Death Discov)
Overexpression of SOX9 reversed the inhibitory effect of OTUD1 on the resistance of NSCLC cells to erlotinib. In conclusion, our study reveals that OTUD1 potentially acts as a tumor suppressor and suppresses erlotinib resistance of NSCLC through the YAP1/SOX9/SPP1 axis, suggesting that OTUD1 may serve as a target for reducing chemoresistance for NSCLC.
Journal
|
YAP1 (Yes associated protein 1) • SPP1 (Secreted Phosphoprotein 1) • SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • YAP1 overexpression • SOX9 expression
|
erlotinib
over1year
Clinicopathological and prognostic significance of SOX9 expression in gastric cancer patients: A meta-analysis. (PubMed, Medicine (Baltimore))
SOX9 overexpression might be related to poor prognosis and could serve as a potential predictive marker of poor clinicopathological prognosis factor in GC patients.
Retrospective data • Journal
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SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
over1year
SOX9 and IL1A as the potential gene biomarkers of the oral cancer. (PubMed, Comb Chem High Throughput Screen)
SOX9 and IL1A genes are highly expressed in oral cancer and might be potential therapeutic targets for oral cancer. The poor overall survival of patients with the high expression of SOX9 and IL1A.
Journal
|
IL10 (Interleukin 10) • SOX9 (SRY-Box Transcription Factor 9) • IL1A (Interleukin 1, alpha) • YBX1 (Y-Box Binding Protein 1)
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SOX9 overexpression • SOX9 expression
2years
iTRAQ-Based Proteome Profiling of Differentially Expressed Proteins in Insulin-Resistant Human Hepatocellular Carcinoma. (PubMed, Front Cell Dev Biol)
parallel reaction monitoring (PRM) and Western blot analysis were applied to verify the protein level of these four key nodes mentioned above, which showed the same trend as quantified by isobaric tags for relative and absolute quantitation (iTRAQ) and confirmed the reliability of our Proteome Profiling analysis. Our results indicated that IR related dysregulation of protein expression might participated in tumorigenesis and malignant phenotype of hepatocarcinoma cells.
Journal
|
YAP1 (Yes associated protein 1) • SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
2years
SOX9 Triggers Different Epithelial to Mesenchymal Transition States to Promote Pancreatic Cancer Progression. (PubMed, Cancers (Basel))
Our results indicate that SOX9 facilitates PDAC progression and metastasis by triggering stemness and EMT.
Journal
|
KRAS (KRAS proto-oncogene GTPase) • CDH1 (Cadherin 1) • VIM (Vimentin) • SOX9 (SRY-Box Transcription Factor 9) • SNAI2 (Snail Family Transcriptional Repressor 2)
|
CDH1 expression • SOX9 overexpression • VIM expression • SOX9 expression
|
gemcitabine
2years
SOX9/MKLN1-AS Axis Induces Hepatocellular Carcinoma Proliferation and Epithelial-Mesenchymal Transition. (PubMed, Biochem Genet)
According to dual luciferase reporter and ChIP assays, SOX9 can bind to the promoter of MKLN1-AS gene to stimulate the expression. MKLN1-AS is transcriptionally regulated by SOX9 and mediates the effects of SOX9 on the proliferation and EMT of HCCs.
Journal
|
CDH1 (Cadherin 1) • VIM (Vimentin) • SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
2years
Prognostic and diagnostic value of SOX9 in cirrhotic and noncirrhotic hepatocellular carcinoma. (PubMed, Transl Cancer Res)
High SOX9 expression may aid prognostic evaluation in NCHCC but not in CHCC. SOX9 expression was not different between CHCC and NCHCC, but it has reliable and comparable diagnostic value in both CHCC and NCHCC.
Journal
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AFP (Alpha-fetoprotein) • SOX2 • SOX9 (SRY-Box Transcription Factor 9)
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SOX9 overexpression • SOX9 expression
2years
Hypoxia inducible factor-3α promotes osteosarcoma progression by activating KDM3A-mediated demethylation of SOX9. (PubMed, Chem Biol Interact)
The Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway inhibitor cucurbitacin I suppressed the promotive effects of HIF-3α overexpression on cell proliferation, invasion and TAK2/STAT3 pathway. Finally, OS cell line MG-63 transfected with HIF-3α short hairpin RNA (HIF-3α shRNA) were subcutaneously injected into nude mice, and the results found that HIF-3α knockdown significantly inhibited the xenograft tumor growth of OS in vivo. In conclusion, this study reveals that HIF-3α promotes OS progression in vitro and in vivo by activating KDM3A-mediated SOX9 promoter demethylation, which may provide a potential therapeutic mechanism for OS.
Journal
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EPAS1 (Endothelial PAS domain protein 1) • SOX9 (SRY-Box Transcription Factor 9) • YBX1 (Y-Box Binding Protein 1)
|
SOX9 overexpression
|
cucurbitacin I (JSI-124)
over2years
Diagnostic and Prognostic Significances of SOX9 in Thymic Epithelial Tumor. (PubMed, Front Oncol)
SOX9 may serve as a diagnostic and prognostic marker for TETs. Notably, high SOX9 expression in TETs may indicate a tuft cell phenotype and an immune suppressive microenvironment of thymomas.
Journal • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • SOX9 (SRY-Box Transcription Factor 9) • TGFB1 (Transforming Growth Factor Beta 1)
|
PD-L1 expression • SOX9 overexpression • SOX9 expression
over2years
The Clinicopathological and Prognostic Significance of SOX9 Expression in Gastric Cancer: Meta-Analysis and TCGA Analysis. (PubMed, Front Oncol)
SOX9 may be a potential prognostic factor for GC patients but needs further study. PROSPERO, ID NUMBER 275712.
Retrospective data • Review
|
SOX9 (SRY-Box Transcription Factor 9) • YBX1 (Y-Box Binding Protein 1)
|
SOX9 overexpression • SOX9 expression
over2years
Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis. (PubMed, JCI Insight)
Using a mouse model of bleomycin-induced pulmonary fibrosis, we show that myofibroblast-specific Sox9 overexpression augments fibroblast activation and pulmonary fibrosis. Thus, Sox9 functions as a profibrotic transcription factor in activating fibroblasts, illustrating the potential utility of targeting Sox9 in IPF treatment.
Journal
|
WT1 (WT1 Transcription Factor) • SOX9 (SRY-Box Transcription Factor 9) • TGFA (Transforming Growth Factor Alpha)
|
SOX9 overexpression • SOX9 expression
|
bleomycin
over2years
PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer. (PubMed, Front Biosci (Landmark Ed))
Moreover, PLOD1 downregulation inhibited tumor formation in vivo. This study showed that PLOD1can promote cell growth and aerobic glycolysis through activating the SOX9/PI3K/Akt/mTOR signaling.
Journal
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LDHA (Lactate dehydrogenase A) • SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
almost3years
SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer. (PubMed, Oncogene)
High expression of SOX9 and TSPAN8 has been associated with tumor stage, poor prognosis and poor patient survival in PDAC. In conclusion, this study highlights the importance of the EGF-SOX9-TSPAN8 signaling cascade in the control of PDAC invasion and implies that TSPAN8 may be a promising novel therapeutic target for the treatment of PDAC.
Journal
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EGFR (Epidermal growth factor receptor) • SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
almost3years
SOX9 promotes epidermal growth factor receptor-tyrosine kinase inhibitor resistance via targeting β-catenin and epithelial to mesenchymal transition in lung cancer. (PubMed, Life Sci)
SOX9 expression could provide an innovative perspective as biomarker to understand the EGFR-TKIs resistance in lung cancer.
Journal
|
EGFR (Epidermal growth factor receptor) • SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
|
gefitinib
almost3years
The SOX9-MMS22L Axis Promotes Oxaliplatin Resistance in Colorectal Cancer. (PubMed, Front Mol Biosci)
In CRC, activation of the SOX9-MMS22L-dependent DNA damage pathway is a core pathway regulating oxaliplatin sensitivity. Targeting this pathway in oxaliplatin-resistant CRC cells is a promising therapeutic option.
Journal
|
SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
|
oxaliplatin
almost3years
Transformation of SOX9 cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma. (PubMed, Sci Rep)
To address this question, we developed a liver cancer mouse model (Pten; Sox9-Cre; R26R) where tumor suppressor Pten (phosphatase and tensin homolog deleted on chromosome ten) is deleted in SOX9 cells following tamoxifen injection...We further examine the mechanisms underlying tumor formation in this model to show that concurrent with the induction of niche signal (i.e., Wnt signaling), liver injury significantly stimulates the expansion of tumor-initiating cells (TICs). Together, these data show that (1) SOX9 cells have the potential to become TICs following the primary transformation (i.e. Pten deletion) and that (2) liver injury is necessary for promoting the activation and proliferation of transformed SOX9 cells, resulting in the genesis of mixed-lineage liver tumors.
Journal
|
PTEN (Phosphatase and tensin homolog) • SOX2 • SOX9 (SRY-Box Transcription Factor 9)
|
PTEN deletion • SOX9 overexpression • SOX9 expression
|
tamoxifen
almost3years
SOX9 is associated with advanced T-stages of clinical stage II colon cancer in young Mexican patients. (PubMed, Oncol Lett)
The present study was the first to evaluate the expression levels of SOX9 in Mexican patients diagnosed with early-stage CC. The aforementioned findings indicated that high SOX9 expression could play an important role in tumorigenesis and be associated with advanced T-stages of clinical-stage II patients, but not with relapse-free survival.
Clinical • Journal
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SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
3years
Up-regulation of sex-determining region Y-box 9 (SOX9) in growth hormone-secreting pituitary adenomas. (PubMed, BMC Endocr Disord)
The study provided the first shreds of evidence regarding the expression pattern of SOX9 in the GH- secreting pituitary adenomas at both gene and protein levels which may emphasize the possible involvement of SOX9 as a mediator in pituitary adenoma tumor formation also open up new intrinsic molecular mechanism regarding pituitary adenoma pathogenesis.
Journal
|
SOX2 • SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
over3years
Circ_0109046 promotes the malignancy of endometrial carcinoma cells through the microRNA-105/SOX9/Wnt/β-catenin axis. (PubMed, IUBMB Life)
This study evidenced that Circ_0109046 upregulates SOX9 expression through sponging miR105, leading to activation of Wnt/β-catenin signaling and the malignant growth of EC. This study may offer novel understanding in EC treatment.
Journal
|
SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
over3years
LncRNA SRA1 is downregulated in HPV-negative cervical squamous cell carcinoma (CSCC) and regulates cancer cell behaviors. (PubMed, Biosci Rep)
In addition, miR-9 overexpression attenuated the effects of SRA1 overexpression. Therefore, SRA1 is downregulated in HPV-negative CSCC and regulates cancer cell behaviors possibly by downregulating miR-9.
Journal
|
SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression
over3years
Up-regulation of miRNA-105 inhibits the progression of gastric carcinoma by directly targeting SOX9. (PubMed, Eur Rev Med Pharmacol Sci)
These results revealed the crucial role of miR-105 in the progression and metastasis of gastric carcinoma, which indicated the potential application of miR-105 in the treatment of gastric carcinoma.
Journal
|
SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
over3years
Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness. (PubMed, Cell Rep)
Overexpression of miR124 depletes SOX9 in vivo and promotes a stem-like-to-neuronal transition, with reduced tumorigenicity and increased radiation sensitivity. Providing a rationale for reports demonstrating miR-124-induced abrogation of GBM aggressiveness, we conclude that reversal of an ERK1/2-miR-124-SOX9 axis induces a neuronal phenotype and that enforcing neuronal differentiation represents a therapeutic strategy to improve outcomes in GBM.
Journal
|
SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression • SOX9 expression
over3years
SOX9: The Master Regulator of Cell Fate in Breast Cancer. (PubMed, Biochem Pharmacol)
In general, this review article aims to serve as an ample source of knowledge on the involvement of SOX9 in BC progression. Targeting SOX9 activity may improve therapeutic strategies to treat BC, but precisely inhibiting SOX9 using drugs and/or small peptides remains a huge challenge for forthcoming cancer research.
Review • Journal
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SOX9 (SRY-Box Transcription Factor 9)
|
SOX9 overexpression