^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    SOX18 (SRY-Box Transcription Factor 18)

    i
    Other names: SOX18, SRY-Box Transcription Factor 18, SRY (Sex Determining Region Y)-Box 18, Transcription Factor SOX-18, SRY-Box 18, HLTRS, HLTS
    Associations

    News

    Trials
    2ms
    Molecular Mechanism of SOX18 in Lipopolysaccharide-Induced Injury of Human Umbilical Vein Endothelial Cells. (PubMed, Crit Rev Immunol)
    miR-204-5p knockdown and CDH2 overexpression abrogated the protective role of SOX18 in HUVECs injury. Overall, SOX18 alleviated LPS-induced injury of HUVECs by promoting miR-204-5p and repressing CDH2, suggesting it as a potential target for sepsis treatment.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDH2 (Cadherin 2) • IL1B (Interleukin 1, beta) • MIR204 (MicroRNA 204) • SOX18 (SRY-Box Transcription Factor 18)
    2ms
    TGF-β1 Induced SOX18 Elevation Promotes Hepatocellular Carcinoma Progression and Metastasis through Transcriptionally Upregulating PD-L1 and CXCL12. (PubMed, Gastroenterology)
    SOX18 promoted the accumulation of immunosuppressive TAMs and Tregs in microenvironment by transactivating CXCL12 and PD-L1. CXCR4 inhibitor or TGFβR1 inhibitor in synergy with anti-PD-L1 represented a promising combination strategy to suppress HCC progression and metastasis.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • HMGB1 (High Mobility Group Box 1) • TGFB1 (Transforming Growth Factor Beta 1) • SMAD2 (SMAD Family Member 2) • SOX18 (SRY-Box Transcription Factor 18)
    |
    vactosertib (TEW-7197) • plerixafor
    5ms
    GPNMB Gal-3 hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogenesis. (PubMed, EMBO J)
    Enrichment of the GPNMB Gal-3 MT subset was found to be associated with poor prognosis and a higher rate of recurrence in patients. Collectively, we unraveled the single-cell HCC progression atlas and uncovered GPNMB Gal-3 parenchymal cells as a major subset contributing to the immunosuppressive microenvironment thus malignance in HCC.
    Journal
    |
    EPCAM (Epithelial cell adhesion molecule) • LGALS3 (Galectin 3) • GPNMB (Glycoprotein Nmb) • SOX18 (SRY-Box Transcription Factor 18)
    9ms
    Targeting SOX18 Transcription Factor Activity by Small-Molecule Inhibitor Sm4 in Non-Small Lung Cancer Cell Lines. (PubMed, Int J Mol Sci)
    These results suggest that Sm4 has the potential to disrupt the cell cycle and target cancer cell growth by modulating SOX18 activity and p21 expression. Further investigation is necessary to fully understand the relationship between SOX18 and p21 in lung cancer and to explore the therapeutic potential of SOX18 inhibition in lung cancer.
    Preclinical • Journal
    |
    SOX17 (SRY-Box Transcription Factor 17) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • SOX18 (SRY-Box Transcription Factor 18)