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    BIOMARKER:

    SOX17 overexpression

    i
    Other names: SOX17, SRY-Box Transcription Factor 17, SRY (Sex Determining Region Y)-Box 17, Transcription Factor SOX-17, SRY-Box 17, SRY-Related HMG-Box Transcription Factor SOX17, SOX17, VUR3
    Entrez ID:
    64321
    Related biomarkers:
    Others
    3ms
    SOX17 expression in mesonephric-like adenocarcinomas and mesonephric remnants/hyperplasia of the female genital tract: Expanding its utility as a Müllerian biomarker. (PubMed, Histopathology)
    The majority of MLA are negative or exhibit low SOX17 expression, in contrast to the diffuse and strong expression commonly seen in other types of Müllerian carcinoma. However, a subset of MLAs demonstrate high SOX17 expression. Therefore, absence of SOX17 staining is supportive for MLA when the differential includes another non-mucinous Müllerian carcinoma. SOX17 may also be useful for differentiating mesonephric remnants/hyperplasias from Müllerian malignancies and benign Müllerian glandular lesions.
    Journal
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    SOX17 (SRY-Box Transcription Factor 17) • PAX8 (Paired box 8)
    |
    SOX17 overexpression
    over2years
    CUX2/KDM5B/SOX17 axis affects the occurrence and development of breast cancer. (PubMed, Endocrinology)
    This study highlights that suppression of CUX2 inhibits KDM5B to repress tumorigenesis and progression of BC through overexpressing SOX17.
    Journal
    |
    SOX2 • SOX17 (SRY-Box Transcription Factor 17) • KDM5B (Lysine Demethylase 5B)
    |
    SOX17 overexpression
    over2years
    miR-200a-3p promoted cell proliferation and metastasis by downregulating SOX17 in non-small cell lung cancer cells. (PubMed, J Biochem Mol Toxicol)
    In the end, we found that overexpressed SOX17 can reverse miR-200a-3p's impact on NSCLC cell proliferation and metastasis. Therefore, this study demonstrated that miR-200a-3p influences NSCLC cell proliferation and metastasis by modulating the levels of SOX17.
    Journal
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    SOX17 (SRY-Box Transcription Factor 17) • MIR200A (MicroRNA 200a)
    |
    SOX17 overexpression
    over3years
    SOX17 Antagonizes the WNT Signaling Pathway and is Epigenetically Inactivated in Clear-Cell Renal Cell Carcinoma. (PubMed, Onco Targets Ther)
    In summary, our study showed that SOX17 is downregulated in ccRCC and the loss of SOX17 expression is regulated via epigenetic mechanisms in ccRCC. In addition, SOX17 negatively regulates the WNT signaling pathway and function as a tumor suppressor in ccRCC.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • SOX17 (SRY-Box Transcription Factor 17)
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    SOX17 overexpression • SOX17 methylation