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    BIOMARKER:

    SOX17 methylation

    i
    Other names: SOX17, SRY-Box Transcription Factor 17, SRY (Sex Determining Region Y)-Box 17, Transcription Factor SOX-17, SRY-Box 17, SRY-Related HMG-Box Transcription Factor SOX17, SOX17, VUR3
    Entrez ID:
    64321
    Related biomarkers:
    Expression
    1year
    Non-small Cell Lung Cancer Epigenomes Exhibit Altered DNA Methylation in Smokers and Never-smokers. (PubMed, Genomics Proteomics Bioinformatics)
    For example, 71% of recurrent promoter hypoDMRs contained a motif for NKX2-1. Finally, the majority of DMRs were located within an active chromatin state in tissues profiled using the Roadmap Epigenome data, suggesting that methylation changes may contribute to altered regulatory programs through the adaptation of cell type-specific expression programs.
    Journal • Epigenetic controller
    |
    TOP2A (DNA topoisomerase 2-alpha) • SOX17 (SRY-Box Transcription Factor 17) • ASPSCR1 (ASPSCR1 Tether For SLC2A4) • SEPTIN9 (Septin 9)
    |
    SOX17 methylation
    over3years
    SOX17 Antagonizes the WNT Signaling Pathway and is Epigenetically Inactivated in Clear-Cell Renal Cell Carcinoma. (PubMed, Onco Targets Ther)
    In summary, our study showed that SOX17 is downregulated in ccRCC and the loss of SOX17 expression is regulated via epigenetic mechanisms in ccRCC. In addition, SOX17 negatively regulates the WNT signaling pathway and function as a tumor suppressor in ccRCC.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • SOX17 (SRY-Box Transcription Factor 17)
    |
    SOX17 overexpression • SOX17 methylation