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    GENE:

    SOX14 (SRY-Box Transcription Factor 14)

    i
    Other names: SOX14, SRY-Box Transcription Factor 14, SOX28, SRY (Sex Determining Region Y)-Box 14, HMG Box Transcription Factor SOX-14, Transcription Factor SOX-14, SRY-Box 14, Protein SOX-28
    Associations

    News

    Trials
    1year
    Association between SOX gene family expression, DNA methylation, and miRNA regulation in lung adenocarcinoma progression. (PubMed, Discov Oncol)
    The SOX gene family is closely implicated in the onset and progression of lung adenocarcinoma, of which most members may be used as prognostic marker genes for patients.
    Journal
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    SOX2 • SOX17 (SRY-Box Transcription Factor 17) • MIR499A (MicroRNA 499a) • SOX18 (SRY-Box Transcription Factor 18) • SOX4 (SRY-Box Transcription Factor 4) • SOX8 (SRY-Box Transcription Factor 8) • SOX14 (SRY-Box Transcription Factor 14)
    over1year
    TGF-β superfamily-induced transcriptional activation pathways establish the RAD52-dependent ALT machinery during malignant transformation of MPNSTs. (PubMed, Sci Rep)
    Telomere elongation achieved by the activation of PAX7 and PAX9 is associated with a poor prognosis. We demonstrated that TGF-β superfamily-induced transcriptional activation pathways activated the RAD52-dependent ALT during malignant transformation of MPNSTs.
    Journal
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    BRCA2 (Breast cancer 2, early onset) • NF1 (Neurofibromin 1) • TGFB1 (Transforming Growth Factor Beta 1) • RAD52 (RAD52 Homolog DNA Repair Protein) • FEN1 (Flap Structure-Specific Endonuclease 1) • PAX7 (Paired Box 7) • SLX4 (SLX4 Structure-Specific Endonuclease Subunit) • SOX4 (SRY-Box Transcription Factor 4) • BMP2 (Bone Morphogenetic Protein 2) • BMP4 (Bone Morphogenetic Protein 4) • SOX14 (SRY-Box Transcription Factor 14)
    over2years
    Joint analysis of WES and RNA-Seq identify signature genes related to metastasis in prostate cancer. (PubMed, J Cell Mol Med)
    Our study provides new molecular perspectives on PCa metastasis. The signature genes and pathways could be served as potential therapeutic targets for metastasis or cancer progression.
    Journal • BRCA Biomarker
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    BRCA2 (Breast cancer 2, early onset) • TTN (Titin) • CD34 (CD34 molecule) • FOXA1 (Forkhead Box A1) • AGR3 (Anterior Gradient 3, Protein Disulphide Isomerase Family Member) • SOX4 (SRY-Box Transcription Factor 4) • NCOA1 (Nuclear Receptor Coactivator 1) • SOX14 (SRY-Box Transcription Factor 14) • UBL4A (Ubiquitin Like 4A)
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    TTN mutation