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    GENE:

    SOX10 (SRY-Box 10)

    i
    Other names: SOX10, SRY-Box 10, SRY-Related HMG-Box Gene 10, Transcription Factor SOX-10, SRY Box 10, WS2E, WS4C
    1d
    Efficient Induction of Oligodendrocyte Lineage From Pluripotent Stem Cells via Temporal Modulation of OLIG2(S147A) and SOX10. (PubMed, Genes Cells)
    In contrast, sustained doxycycline-mediated expression of SOX10 and OLIG2(S147A) favored OPC proliferation and delayed OL maturation. These findings highlight the importance of temporal control of transcription factor activity in accelerating OL differentiation and provide a practical platform for disease modeling and regenerative applications.
    Journal
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    SOX10 (SRY-Box 10) • OLIG2 (Oligodendrocyte Transcription Factor 2)
    1d
    Spitz Melanocytoma With a Novel CPEB2::MAP3K2 Rearrangement: A Case Report. (PubMed, J Cutan Pathol)
    A conservative re-excision was performed, and a PET/CT scan showed no evidence of dissemination. With 16 months of follow-up available, longer-term monitoring will be required to determine the clinical behavior and biologic potential of this tumor.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • CCND1 (Cyclin D1) • SOX10 (SRY-Box 10) • PRAME (Preferentially Expressed Antigen In Melanoma) • MLANA (Melan-A) • MITF (Melanocyte Inducing Transcription Factor) • RREB1 (Ras Responsive Element Binding Protein 1)
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    TMB-L
    6d
    Changes in Blood DNA CpG Methylation Levels in Response to Methadone Maintenance Treatment: Epigenome-Wide Longitudinal Study. (PubMed, Epigenomes)
    The study provides preliminary insight into the epigenetic effect of MMT. Future studies will have to confirm the DMPs, assess their impact on gene expression, and determine their clinical relevance.
    Observational data • Journal
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    SOX10 (SRY-Box 10) • GNAS (GNAS Complex Locus) • CRY1, Cryptochrome Circadian Regulator 1, • DNMT3B (DNA Methyltransferase 3 Beta) • ADORA2A (Adenosine A2a Receptor) • CREB1 (CAMP Responsive Element Binding Protein 1) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
    6d
    PRAME Expression in Melanoacanthomas: Expanding the Spectrum of Positive Melanocytes in Sun-Exposed Skin. (PubMed, Dermatopathology (Basel))
    Moreover, high-intensity PRAME expression showed a positive association with increasing grades of solar elastosis. These findings indicate that strong PRAME expression in melanoacanthoma could be associated with chronic sun damage and may reflect non-specific, ultraviolet-related modulation rather than malignant transformation, underscoring the importance of contextual interpretation of PRAME immunohistochemistry in diagnostic practice.
    Journal
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    SOX10 (SRY-Box 10) • PRAME (Preferentially Expressed Antigen In Melanoma)
    6d
    Cutaneous Granular Cell Tumor with Overlying Hypertrichosis in an Adult: A Rare Case Report. (PubMed, Dermatopathology (Basel))
    To our knowledge, this represents the second reported instance of a cutaneous granular cell tumor associated with hypertrichosis and the first described in an adult. It underscores the importance of clinicopathologic correlation in evaluating unusual cutaneous lesions and expands the spectrum of recognized presentations of cutaneous granular cell tumors.
    Journal
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    SOX10 (SRY-Box 10) • CD68 (CD68 Molecule)
    8d
    Tracheal schwannoma presenting as pneumonia: A rare case report in an adolescent. (PubMed, Respir Med Case Rep)
    For adolescent patients with recurrent respiratory symptoms and poor response to conventional therapy, early chest CT and bronchoscopy should be considered. Bronchoscopic resection combined with anti-infective therapy can achieve excellent outcomes.
    Journal
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    SOX10 (SRY-Box 10)
    8d
    Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease. (PubMed, Signal Transduct Target Ther)
    Similarly, intracerebroventricular (ICV) administration of Sox10 promoter-driven AAV-Bmp4 efficiently ameliorated AD progression. Collectively, these findings uncover an OPC-microglia crosstalk that governs immune surveillance in AD, highlighting COP-targeted enhancement of Bmp4 as a promising avenue for interventions aimed at reinforcing early neuroprotective responses.
    Journal
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    SOX10 (SRY-Box 10) • TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) • BMP4 (Bone Morphogenetic Protein 4)
    9d
    Multinodular and vacuolating neuronal tumor: molecular genetics and DNA methylation analysis of 12 cases. (PubMed, J Pathol)
    Only one patient died 16 months after surgery due to an unrelated traffic accident.
    Journal
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    EGFR (Epidermal growth factor receptor) • BRAF (B-raf proto-oncogene) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • TERT (Telomerase Reverse Transcriptase) • SOX10 (SRY-Box 10) • GFAP (Glial Fibrillary Acidic Protein) • OLIG2 (Oligodendrocyte Transcription Factor 2)
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    BRAF V600E • BRAF V600 • IDH1 mutation • IDH2 mutation • FGFR2 mutation • FGFR2 fusion • IDH mutation + BRAF V600E
    9d
    Polypoid Melanoma: A Rare and Aggressive Variant. (PubMed, Cureus)
    Management emphasizes timely wide excision and accurate pathologic staging, with multidisciplinary coordination and consideration of adjuvant systemic therapy (such as immune checkpoint inhibitors or targeted agents) when indicated by stage. This case highlights the need to maintain a high index of suspicion for PM in atypical, rapidly growing, or bleeding cutaneous nodules.
    Journal
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    SOX10 (SRY-Box 10)
    9d
    Axial Round Cell Sarcoma Harboring a Non-ETS EWSR1 Rearrangement: Diagnostic Challenges and Clinical Implications. (PubMed, Cureus)
    Surgical resection and cervicothoracic fixation were performed, followed by radiotherapy (30 Gy/10 fractions) and Ewing-based chemotherapy (doxorubicin/ifosfamide). Local recurrence occurred despite multimodal therapy. This case highlights the clinical and diagnostic challenges associated with EWSR1-rearranged non-ETS sarcomas, which exhibit distinct molecular behaviors, morphology, and treatment responses compared to classical Ewing sarcoma.
    Journal
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    CCND1 (Cyclin D1) • EWSR1 (EWS RNA Binding Protein 1) • SOX10 (SRY-Box 10) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • CD99 (CD99 Molecule)
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    doxorubicin hydrochloride • ifosfamide
    14d
    LncRNA Dlx4os drives malignant transformation and phenotype switching in melanoma. (PubMed, Epigenetics)
    Furthermore, we identified a human orthologue of Dlx4os. Our findings highlight the potential of Dlx4os as both a biomarker and therapeutic target, capable of modulating melanoma's phenotypic plasticity to influence treatment response and metastasis.
    Journal
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    SOX10 (SRY-Box 10) • TGFB1 (Transforming Growth Factor Beta 1) • MLANA (Melan-A) • MITF (Melanocyte Inducing Transcription Factor)
    14d
    Mucosal melanoma of the head and neck region: clinical-pathologic implications of tumor microenvironment evaluated with multiplex immunohistochemistry. (PubMed, Virchows Arch)
    Notably, a distinct "TME phenotype" (CD3low/CD20high/CD68high) is linked with unfavorable features - such as LVI and advanced pT4a/pT4b staging - as well as the need for more aggressive therapies. We also observed discordant TME and molecular results in consecutive samples from a subset of patients, suggesting heterogeneity that may potentially affect prognosis and therapeutic strategies.
    Journal
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    CD20 (Membrane Spanning 4-Domains A1) • SOX10 (SRY-Box 10) • CD68 (CD68 Molecule)