^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    SOSTDC1 (Sclerostin Domain Containing 1)

    i
    Other names: SOSTDC1, Sclerostin Domain Containing 1, USAG1, DAND7, Sclerostin Domain-Containing Protein 1, Ectodermal BMP Inhibitor, DKFZp564D206, Ectodin, Wise, Uterine Sensitization-Associated Gene 1 Protein, Uterine Sensitization-Associated Protein-1, Cystine-Knot Containing Secreted Protein, ECTODIN, CDA019, USAG-1
    Associations

    News

    Trials
    1year
    Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia. (PubMed, BMC Cancer)
    HOXA9 methylation linked to HOXA9 expression correlates with diverse genetic abnormalities of AML, such as normal karyotype, t(15;17), t(8;21), t(16;16) and FLT3, NPM1 and DNMT3A mutations. Moreover, HOXA9 hypomethylation may be associated with adverse prognosis, and may guide treatment choice in AML.
    Journal
    |
    FLT3 (Fms-related tyrosine kinase 3) • NPM1 (Nucleophosmin 1) • DNMT3A (DNA methyltransferase 1) • KMT2A (Lysine Methyltransferase 2A) • NUP98 (Nucleoporin 98 And 96 Precursor 2) • HOXA9 (Homeobox A9) • HOTAIR (HOX Transcript Antisense RNA) • MIR193B (MicroRNA 193b) • MIR381 (MicroRNA 381) • MEG3 (Maternally Expressed 3) • SOSTDC1 (Sclerostin Domain Containing 1)
    |
    FLT3-ITD mutation • NPM1 mutation • KMT2A rearrangement • Chr t(15;17)
    1year
    Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors. (PubMed, Onco Targets Ther)
    Vitamin D has been shown to inhibit the proliferation and migration of colon cancer cells and reduce the expression of oncogenes. Therefore, vitamin D holds substantial potential for the diagnosis and treatment of CRC.
    Journal
    |
    CCND1 (Cyclin D1) • CEACAM1 (CEA Cell Adhesion Molecule 1) • MMP1 (Matrix metallopeptidase 1) • PRKAA2 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 2) • SOSTDC1 (Sclerostin Domain Containing 1)
    over1year
    SOSTDC1 Nuclear Translocation Facilitates BTIC Maintenance and CHD1-Mediated HR Repair to Promote Tumor Progression and Olaparib Resistance in TNBC. (PubMed, Adv Sci (Weinh))
    Furthermore, nuclear SOSTDC1 bound to β-transducin repeat-containing protein (β-TrCP) binding motifs of CHD1 is found, thereby blocking the β-TrCP-CHD1 interaction and inhibiting β-TrCP-mediated CHD1 ubiquitination and degradation. Collectively, these findings identify a novel nuclear SOSTDC1 pathway in regulating HR repair and BTIC maintenance, providing insight into the TNBC therapeutic strategies.
    Journal
    |
    CHD1 (Chromodomain Helicase DNA Binding Protein 1) • SOSTDC1 (Sclerostin Domain Containing 1)
    |
    Lynparza (olaparib)
    almost2years
    Comprehensive proteogenomic characterization of rare kidney tumors. (PubMed, Cell Rep Med)
    Expression of biomarkers MAPRE3, ADGRF5, and GPNMB differentiates renal oncocytoma from chromophobe RCC, and PIGR and SOSTDC1 distinguish papillary RCC from MTSCC. This study expands our knowledge of proteogenomic signatures, biomarkers, and potential therapeutic targets in non-ccRCC.
    Journal • IO biomarker
    |
    GPNMB (Glycoprotein Nmb) • PYCR1 (Pyrroline-5-Carboxylate Reductase 1) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) • SOSTDC1 (Sclerostin Domain Containing 1)
    |
    IGF2 overexpression
    2years
    The role of basic leucine zipper transcription factor E4BP4 in cancer: a review and update. (PubMed, Mol Biol Rep)
    Moreover, recent studies have shown that E4BP4 inhibited the expression of multidrug resistance genes. In this review, we summarize the molecular mechanism of E4BP4 in cancer cellular process, the effects of E4BP4 in cancer immunotherapy and antitumor drug resistance, to provide theoretical basis for tumor treatment strategies targeting E4BP4.
    Review • Journal • IO biomarker
    |
    IFNG (Interferon, gamma) • TGFB1 (Transforming Growth Factor Beta 1) • NFKBIA (NFKB Inhibitor Alpha 2) • GADD45B (Growth Arrest And DNA Damage Inducible Beta) • PRNP (Prion Protein) • SMAD3 (SMAD Family Member 3) • SOSTDC1 (Sclerostin Domain Containing 1)
    almost3years
    Single-cell profiling reveals sustained immune infiltration, surveillance, and tumor heterogeneity in infiltrative BCC. (PubMed, J Invest Dermatol)
    The high expression of malignant basal 2 cell markers was associated with the invasion and recurrence of iBCC. Altogether, our study helps elucidate the cellular heterogeneity in iBCC and provides potential therapeutic targets for clinical research.
    Journal
    |
    CXCL13 (Chemokine (C-X-C motif) ligand 13) • IGFBP5 (Insulin Like Growth Factor Binding Protein 5) • SFRP1 (Secreted frizzled related protein 1) • SOSTDC1 (Sclerostin Domain Containing 1)
    3years
    Identification and Analysis of Crucial Genes in H. pylori-Associated Gastric Cancer Using an Integrated Bioinformatics Approach. (PubMed, J Oncol)
    Patients with higher levels of C3 expression had a poorer prognosis than those with lower levels. In addition, these key genes may serve as biomarkers and therapeutic targets for H. pylori-associated GC diagnosis, targeted therapy, and immunotherapy in the future.
    Journal • IO biomarker
    |
    FCER1G (Fc Fragment Of IgE Receptor Ig) • SOSTDC1 (Sclerostin Domain Containing 1)
    over3years
    Role of Sostdc1 in skeletal biology and cancer. (PubMed, Front Physiol)
    Recently, Sostdc1 has been found to be closely related to the development and progression of multiple cancer types, including breast, renal, gastric, and thyroid cancers. This article summarises the role of Sostdc1 in skeletal biology and related cancers to provide a theoretical basis for the treatment of related diseases.
    Review • Journal
    |
    SOSTDC1 (Sclerostin Domain Containing 1)
    over3years
    SOSTDC1 acts as a tumor inhibitor in acute myeloid leukemia by downregulating the Wnt/β-catenin pathway. (PubMed, Environ Toxicol)
    Collectively, our work demonstrates that SOSTDC1 has a tumor-inhibiting role in AML via downregulation of the Wnt/β-catenin pathway. This work underscores a key function for the SOSTDC1/Wnt/β-catenin pathway in AML.
    Journal
    |
    SOSTDC1 (Sclerostin Domain Containing 1) • STC1 (Stanniocalcin 1)
    almost4years
    USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction. (PubMed, Cell Death Dis)
    Taken together, our data demonstrate that USP15 can negatively regulate the TRAF6-BECN1 signaling axis for autophagy induction. Thus, USP15 is implicated in lung cancer progression.
    Journal • IO biomarker
    |
    CCNE1 (Cyclin E1) • TLR4 (Toll Like Receptor 4) • MMP9 (Matrix metallopeptidase 9) • MMP11 (Matrix Metallopeptidase 11) • WIF1 (WNT Inhibitory Factor 1) • ZBTB16 (Zinc Finger And BTB Domain Containing 16) • BECN1 (Beclin 1) • ETV4 (ETS Variant Transcription Factor 4) • SOSTDC1 (Sclerostin Domain Containing 1) • TRAF6 (TNF Receptor Associated Factor 6) • UBE2C (Ubiquitin Conjugating Enzyme E2 C) • USP1 (Ubiquitin Specific Peptidase 1)
    almost4years
    Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney. (PubMed, J Pathol)
    Finally, unsupervised clustering revealed two molecular subtypes of MTSCC, displaying different morphology, expression signatures of oxidative phosphorylation, and aggravation. In summary, our analyses identified a three-protein diagnostic panel and molecular subtypes for MTSCC.
    Journal
    |
    SOSTDC1 (Sclerostin Domain Containing 1)