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    DRUG CLASS:

    Sortilin inhibitor

    Related drugs:
    13d
    Continuation Study for Latozinemab (clinicaltrials.gov)
    P3, N=17, Terminated, Alector Inc. | N=35 --> 17 | Trial completion date: Nov 2027 --> Jan 2026 | Enrolling by invitation --> Terminated | Trial primary completion date: Jul 2027 --> Sep 2025; The AL001-CS-302 study was terminated because its Phase 3 placebo-controlled parent study (AL001-3) failed to meet the clinical co-primary endpoint of slowing FTD-GRN progression, as measured by the Clinical Dementia Rating® plus National Alzheimer's
    Enrollment change • Trial completion date • Trial termination • Trial primary completion date
    13d
    A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3) (clinicaltrials.gov)
    P3, N=119, Terminated, Alector Inc. | Trial completion date: Aug 2027 --> Jan 2026 | Active, not recruiting --> Terminated; The trial did not meet the clinical co-primary endpoint of slowing FTD-GRN progression, as measured by the Clinical Dementia Rating® plus National Alzheimer's Coordinating Center Frontotemporal Lobar Degeneration Sum of Boxes (CDR® plus NACC FTLD-SB)
    Trial completion date • Trial termination
    4ms
    Open-label Extension Study in Participants With Early Alzheimer's Disease (clinicaltrials.gov)
    P2, N=297, Recruiting, GlaxoSmithKline | N=226 --> 297 | Not yet recruiting --> Recruiting
    Enrollment open • Enrollment change
    4ms
    PQ203 in Advanced Malignant Tumors Including Triple Negative Breast Cancer (clinicaltrials.gov)
    P1, N=80, Recruiting, ProteinQure Inc.
    New P1 trial
    6ms
    Open-label Extension Study in Participants With Early Alzheimer's Disease (clinicaltrials.gov)
    P2, N=226, Not yet recruiting, GlaxoSmithKline
    New P2 trial
    10ms
    TH1902-CTR-0001: TH1902 in Patients With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=70, Active, not recruiting, Theratechnologies | Trial completion date: Dec 2024 --> Jan 2026 | Trial primary completion date: Dec 2024 --> Dec 2025 | Recruiting --> Active, not recruiting
    Enrollment closed • Trial completion date • Trial primary completion date
    |
    CD4 (CD4 Molecule)
    |
    sudocetaxel zendusortide (TH 1902)
    10ms
    PROGRESS-AD: Efficacy and Safety of GSK4527226 [AL101] in Participants With Early Alzheimer's Disease (clinicaltrials.gov)
    P2, N=359, Active, not recruiting, GlaxoSmithKline | Recruiting --> Active, not recruiting
    Enrollment closed
    11ms
    PROGRESS-AD: Efficacy and Safety of GSK4527226 [AL101] in Participants With Early Alzheimer's Disease (clinicaltrials.gov)
    P2, N=282, Recruiting, GlaxoSmithKline | Trial completion date: Feb 2029 --> Nov 2026
    Trial completion date
    1year
    A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2) (clinicaltrials.gov)
    P2, N=33, Completed, Alector Inc. | Active, not recruiting --> Completed | Trial completion date: Jun 2026 --> Jun 2024 | Trial primary completion date: Jan 2026 --> Jun 2024
    Trial completion • Trial completion date • Trial primary completion date
    |
    GRN (Granulin Precursor)
    over1year
    An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation. (PubMed, Front Immunol)
    Our results introduce A3-PGRNC15* as a promising new agent with therapeutic potential for the treatment of frontotemporal dementia. Furthermore, the work highlights means to increase binding affinity through synergistic contribution from two orthogonal polypeptide units.
    Journal
    |
    SORT1 (Sortilin 1) • GRN (Granulin Precursor)
    almost2years
    Sudocetaxel Zendusortide (TH1902) triggers the cGAS/STING pathway and potentiates anti-PD-L1 immune-mediated tumor cell killing. (PubMed, Front Immunol)
    A weekly administration of TH1902 as a single agent in a murine B16-F10 melanoma syngeneic tumor model demonstrated superior tumor growth inhibition than did docetaxel. TH1902 inhibited cell proliferation and triggered apoptosis and senescence in B16-F10 cells in vitro, while inducing several downstream effectors of the cGAS/STING pathway and the expression of MHC-I and PD-L1. This is the first evidence that TH1902 exerts its antitumor activity, in part, through modulation of the immune tumor microenvironment and that the combination of TH1902 with checkpoint inhibitors (anti-PD-L1) could lead to improved clinical outcomes.
    Journal • PD(L)-1 Biomarker • IO biomarker • Tumor cell
    |
    SORT1 (Sortilin 1) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CASP3 (Caspase 3) • GZMB (Granzyme B)
    |
    docetaxel • sudocetaxel zendusortide (TH 1902)
    almost2years
    PROGRESS-AD: Efficacy and Safety of GSK4527226 [AL101] in Participants With Early Alzheimer's Disease (clinicaltrials.gov)
    P2, N=282, Recruiting, GlaxoSmithKline | Not yet recruiting --> Recruiting
    Enrollment open