SORT1 (Sortilin 1)

These studies demonstrate that sortilin regulates the inflammatory, autophagic, and apoptotic pathways in Müller cells grown in high glucose. Inhibition of sortilin using AF38469 eye drops also reduced I/R-induced retinal damage.

Moreover, 11.1 MBq [177Lu]Lu-DOTA-latozinemab significantly suppressed tumor growth via induction of DNA damage, as evidenced by increased 53BP1 foci. These findings establish the first SORT1-directed theranostic radiopharmaceutical pair, exhibiting high specificity and therapeutic potency for managing SORT1-positive cancers.

These results suggest a model in which sortilin exhibits potential tumor suppressor-like activity by concurrently binding to regulatory elements of cMYC. Sortilin expression in lung adenocarcinoma may be predictive of the efficacy of anti-EGFR therapies.

This review discusses the rationale behind their discovery, the multidisciplinary approach that enabled it, the evidence supporting their use, and their implementation in U.S. clinical practice as a lab-developed test (LDT). We propose this approach as a new diagnostic standard that bridges mechanistic insight with real-world application.

Among β-thalassemia major patients (7-35 years), 73.3% (n = 44/60) were splenectomized; 36 received deferiprone, 19 deferasirox, and 5 deferoxamine. Endocrine disturbances are common in β-thalassemia major despite chelation therapy. Incorporating endocrine assessment into routine practice is essential for early detection and management.

However, the uptake of fluorescent labelled 11H8 and 6D11 antibodies appeared to be high, whereas the killing capacity of the MMAE-conjugated antibodies was less impressive, suggesting the need for further ADC development. These promising proof-of-concept ADCs are designed to exploit molecular and metabolic vulnerabilities in prostate cancer and may have utility for overcoming treatment resistance by simultaneously targeting different forms of the cancer.

In this study, we identified SorCS3 as a novel tumor suppressor candidate in ACC. Although previously thought to be CNS specific, SorCS3 was found to be expressed in ACC tissues and cell lines. Low SorCS3 levels correlated with poor patient survival in the TCGA cohort. Functionally, SorCS3 enhanced endocytosis in ACC cells and physically or indirectly interacted with IGF2R. OE-SorCS3 increased IGF2R protein levels and reduced phosphorylation of Akt/Erk, suggesting tumor-suppressive effects through IGF2R stabilization and signaling inhibition. Overall, our findings highlight the SorCS3-IGF2R axis as a previously unrecognized regulatory mechanism in ACC progression and suggest that receptor trafficking could be a viable therapeutic target in this malignancy.

In vivo therapeutic intervention using engineered PSAP and GPR37 gene-editing virus-loaded hydrogels demonstrated significant improvements in disc structural integrity and matrix composition in preclinical IDD models, with these protective effects being dependent on GPR37 receptor activation. The findings reveal the ACE-PSAP-GPR37 axis as a fundamental regulatory circuit in disc homeostasis, providing new insights into the molecular pathogenesis of IDD while establishing a conceptual framework for targeted therapeutic development.

These findings underscore the complex interplay of the EGFR/SORT1 axis in regulating VM and in driving to the transcriptional regulation of chemoresistance and CSC molecular signatures of GBM associated with VM. These insights could inspire novel therapeutic strategies targeting the EGFR/SORT1 complex in GBM.

These results suggest that miR-146a plays a critical role in the pathogenesis of NSCLC by targeting SORT1, highlighting its potential as a therapeutic target for NSCLC.

Conclusion Our findings suggest that ASAH2 may play a significant role in the pathogenesis of AD, potentially contributing to early molecular changes that precede clinical symptoms. In addition, the identification of a subgroup of lipid- and membrane-associated proteins provides promising candidates for predictive biomarkers that could facilitate earlier diagnosis and offer new insights into the mechanisms underlying disease progression and possible therapeutic targets for AD prevention.

P=N/A, N=203, Completed, Zhejiang Provincial People's Hospital; Zhejiang Provincial People's Hospital