^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    SORL1 deletion

    i
    Other names: SORL1, Sortilin Related Receptor 1, LDLR Relative With 11 Ligand-Binding Repeats, SorLA-1, LR11, Low-Density Lipoprotein Receptor Relative With 11 Ligand-Binding Repeats, Sorting Protein-Related Receptor Containing LDLR Class A Repeats, Sortilin-Related Receptor, C11orf32, Gp250, SorLA, LRP9, Sortilin-Related Receptor L(DLR Class) A Repeats-Containing, Sortilin-Related Receptor L(DLR Class) A Repeats Containing, Chromosome 11 Open Reading Frame 32, Mosaic Protein LR11, SORLA
    Entrez ID:
    6653
    almost2years
    Morphological profiling in human neural progenitor cells classifies hits in a pilot drug screen for Alzheimer's disease. (PubMed, Brain Commun)
    Prediction of novel targets revealed enrichment in pathways associated with neural cell function and Alzheimer's disease. Overall, this work suggests that (i) a quantitative phenotypic metric can distinguish induced pluripotent stem cell-derived SORL1-/- neural progenitor cells from isogenic wild-type controls and (ii) phenotypic screening combined with multi-parametric high-content image analysis is a viable option for drug repurposing and discovery in this human neural cell model of Alzheimer's disease.
    Journal
    |
    SORL1 (Sortilin Related Receptor 1)
    |
    SORL1 deletion