our Premium Content: News alerts, weekly reports and conference planners

GENE:

SOD3 (Superoxide dismutase 3)

News alerts, weekly reports and conference planners

11d

Snail1 Induced Suppression of Proliferation via EGR1, FOXO1, and CEPBγ Creates a Vulnerability for Targeting Apoptotic and Cellular Senescence Pathways. (PubMed, Cancers (Basel))

We identified three new major downstream targets of Snail1 that improve our understanding of the role of EMT in limiting stress signaling, apoptosis, and senescence during cell cycle suppression to create a vulnerability for therapeutic targeting.

11 days ago

Journal

CASP3 (Caspase 3) • CCNB2 (Cyclin B2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • SNAI1 (Snail Family Transcriptional Repressor 1) • EGR1 (Early Growth Response 1) • SOD3 (Superoxide dismutase 3) • CCNG1 (Cyclin G1)

19d

Effects of phosphatidylserine supplementation on growth performance, lipid metabolism, antioxidant capacity, and inflammatory response of juvenile large yellow croaker (Larimichthys crocea) fed with high soybean oil diets. (PubMed, Comp Biochem Physiol B Biochem Mol Biol)

Furthermore, PS reduced hepatic pro-inflammatory cytokine mRNA levels: tumor necrosis factor α(tnf-α), cyclooxygenase 2 (cox-2), and interleukins (il-6, il-1β). In conclusion, dietary inclusion of 0.006%-0.018% PS effectively enhanced growth and antioxidant capacity, altered lipid handling, and affected transcriptional inflammatory responses.

19 days ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • FASN (Fatty acid synthase) • IL1B (Interleukin 1, beta) • LPL (Lipoprotein Lipase) • ACACA (Acetyl-CoA Carboxylase Alpha) • CAT (Catalase) • PPARA (Peroxisome Proliferator Activated Receptor Alpha) • SCD (Stearoyl-CoA Desaturase) • SOD1 (Superoxide Dismutase 1) • SOD3 (Superoxide dismutase 3) • SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1)

2ms

Baicalein Enhances Longevity and Healthspan of C. elegans Through the Insulin/IGF-1 Signaling Pathway. (PubMed, MedComm (2020))

These results elucidate the function of baicalein in promoting longevity and healthspan in C. elegans through modulation of insulin/IGF-1 signaling. Future studies are warranted to explore the applicability of baicalein in human aging to pave the way for innovative antiaging supplement formulations.

2 months ago

Journal

IGF1 (Insulin-like growth factor 1) • SOD3 (Superoxide dismutase 3)

3ms

Identification of tumor initiating cells and early marker genes in normal colonic epithelium that lead to neoplastic transformation. (PubMed, Res Sq)

Conclusions : This study identifies TICs as the developmental origin of neoplastic stem-like states and delineates early transcriptional and pathway reprogramming events that drive the transition from normal to premalignant colonic epithelium. These findings provide new insight into CRC initiation and nominate biomarkers with translational potential for early detection and therapeutic targeting.

3 months ago

Journal

SLC12A2 (Solute Carrier Family 12 Member 2) • GPRC5A (G Protein-Coupled Receptor Class C Group 5 Member A) • SOD3 (Superoxide dismutase 3)

4ms

Integrative Single-Cell and Bulk Transcriptomic Analysis Identifies Macrophage-Related Gene Signatures Predictive of Hepatocellular Carcinoma in Cirrhosis. (PubMed, Genes (Basel))

This study highlights the critical role of macrophage-associated transcriptomic remodeling in liver disease progression. The machine learning-based predictive models offer a promising approach for early diagnosis and clinical decision-making in patients with cirrhosis.

4 months ago

Journal • Gene Signature

TOP2A (DNA topoisomerase 2-alpha) • CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8) • GAS1 (Growth Arrest Specific 1) • KRT19 (Keratin 19) • SOD3 (Superoxide dismutase 3)

5ms

Integrated Analysis of Single-cell and Bulk-RNA Sequencing Data to Identify Redox-related Genes as Prognostic Biomarkers and Therapeutic Targets of Lung Adenocarcinoma With Osimertinib Resistance. (PubMed, Front Biosci (Landmark Ed))

Targeting CAFs represents a promising strategy to overcome osimertinib resistance. Our six-gene redox signature offers a clinical framework for patient risk stratification and novel therapeutic strategy design. Future work will explore these targets to develop new treatments for LUAD.

5 months ago

Journal • Tumor mutational burden

TMB (Tumor Mutational Burden) • SOD3 (Superoxide dismutase 3)

Tagrisso (osimertinib)

5ms

Potential pulmonary toxic effects of Martian dust simulant. (PubMed, iScience)

TLR4 surface and gene expression decreased at medium and high doses. JSC Mars-1 dust increased cytotoxicity, oxidative stress, and immune responses suggesting potential pulmonary toxic effects, providing insight to molecular mechanisms behind potential adverse respiratory effects.

5 months ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • HMOX1 (Heme Oxygenase 1) • HMGB1 (High Mobility Group Box 1) • TLR4 (Toll Like Receptor 4) • SOD3 (Superoxide dismutase 3)

5ms

Cancer-associated fibroblast-derived SOD3 enhances lymphangiogenesis to drive metastasis in lung adenocarcinoma. (PubMed, Angiogenesis)

Furthermore, single-cell transcriptomic analysis of LUAD clinical samples confirms a strong correlation between SOD3 expression in fibroblasts and characteristics of tumor exacerbation, such as lymphangiogenesis and metastasis. These findings underscore new insights into the role of CAF-derived SOD3 in LUAD progression and highlight its potential as a biomarker and therapeutic target.

5 months ago

Journal

SOD3 (Superoxide dismutase 3)

5ms

Synergistic Effects of Novel Xanthone Derivatives and Mild Hyperthermia in Ovarian Cancer: Insights from Gene Expression and In Silico Analyses. (PubMed, Cancers (Basel))

To summarize, the combined therapy of novel xanthone derivatives and mild hyperthermia shows promising results and warrants further investigation to fully elucidate the mechanisms of action underlying these effects.

5 months ago

Journal

HMOX1 (Heme Oxygenase 1) • HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) • CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) • SOD2 (Superoxide Dismutase 2) • SOD3 (Superoxide dismutase 3)

6ms

Roles of Extracellular Superoxide Dismutase in Regulating Cell Migration and Vesicle Trafficking in Dictyostelium and Mammalian Cells. (PubMed, Dev Growth Differ)

Despite evolutionary divergences, both SodC in Dictyostelium and EC-SOD in humans serve to modulate extracellular oxidative cues and maintain cellular function. The conserved and multifaceted roles of extracellular SODs in redox regulation, signaling, vesicle trafficking, and cell migration offer insights relevant to both fundamental biology and disease.

6 months ago

Review • Journal

SOD3 (Superoxide dismutase 3)

6ms

Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression in Caenorhabditis elegans. (PubMed, Anim Cells Syst (Seoul))

Taken together, we concluded that xanthoxyline exerts an anti-aging activity, possibly by activating the DAF-16-dependent stress response, and reduces the risk of Parkinson's disease, in a manner mediated by DAF-16. Xanthoxyline shows promise for the development of novel nutraceuticals against aging and Parkinson's disease.

6 months ago

Journal

SOD3 (Superoxide dismutase 3)

7ms

Balancing between cuproplasia and copper-dependent cell death: molecular basis and clinical implications of ATOX1 in cancer. (PubMed, J Exp Clin Cancer Res)

Moreover, the prognostic value of ATOX1 expression for the clinical outcome of cancer patients needs to be clarified. In this review, we summarize the current state of knowledge about ATOX1 in cancer focusing on its molecular aspects and potential clinical implications.

7 months ago

Review • Journal • IO biomarker

CCND1 (Cyclin D1) • ATP7A (ATPase Copper Transporting Alpha) • SOD3 (Superoxide dismutase 3)