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    GENE:

    SOCS2 (Suppressor Of Cytokine Signaling 2)

    i
    Other names: SOCS2, Suppressor Of Cytokine Signaling 2, STATI2, CIS2, SSI2, Cytokine-Inducible SH2 Protein 2, STAT-Induced STAT Inhibitor 2, Cish2, CIS-2, STAT-Induced STAT Inhibitor-2
    16d
    SEASONAL FLUCTUATIONS IN AMBIENT PARTICULATE MATTER2.5 EXPOSURE DIFFERENTIALLY REGULATE JAK2/STAT3 SIGNALING IN NEVER SMOKING RURAL AND URBAN COHORTS. (PubMed, Free Radic Biol Med)
    Risk modeling further predicted higher PM2.5-attributed lung cancer mortality in UR populations. Collectively, these findings indicated that elevated PM2.5 exposure was associated with early genotoxic and JAK2/STAT3-associated pro-carcinogenic alterations in airway cells and leukocytes of asymptomatic individuals, reflecting heightened biological sensitivity in urban populations.
    Journal
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    EGFR (Epidermal growth factor receptor) • BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • MCL1 (Myeloid cell leukemia 1) • IL6 (Interleukin 6) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • SOCS2 (Suppressor Of Cytokine Signaling 2)
    17d
    miR-194-5p targets SOCS2 to predict pegIFNα treatment response in HBeAg-positive chronic hepatitis B patients. (PubMed, Virol J)
    miR-194-5p may predict pegIFNα response in HBeAg-positive CHB. It regulates interferon signaling by targeting SOCS2 and modulating the JAK-STAT pathway activation, suggesting the miR-194-5p/SOCS2 axis as a potential therapeutic target.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IFNA1 (Interferon Alpha 1) • IL1B (Interleukin 1, beta) • SOCS2 (Suppressor Of Cytokine Signaling 2) • STAT2 (Signal transducer and activator of transcription 2) • MIR194 (MicroRNA 194)
    1m
    Continuous growth hormone (GH) liver impact during the growth period in non-GH-deprived mice. (PubMed, Cell Cycle)
    GHR and SOCS2 mRNA levels were upregulated by continuous GH in both sexes, whereas c-myc and CIS mRNA were mainly induced in female liver. These results indicate that although continuous GH administration in the used dose is not sufficient to promote growth in non-GH-deprived conditions, it may foster hepatic molecular signatures associated with potentially prooncogenic signaling in mice.
    Preclinical • Journal
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    EGFR (Epidermal growth factor receptor) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IGF1 (Insulin-like growth factor 1) • PCNA (Proliferating cell nuclear antigen) • SOCS2 (Suppressor Of Cytokine Signaling 2)
    2ms
    LncRNA PVT1 promotes proliferation, migration and invasion of cholangiocarcinoma by regulating the expression of SOCS2. (PubMed, Sci Rep)
    Notably, the knockdown of PVT1 correlated with an increase in SOCS2 expression, underscoring the regulatory interplay between these two molecules. Ultimately, our findings indicate that lncRNA PVT1 facilitates cholangiocarcinoma progression by repressing SOCS2 expression, positioning SOCS2 as a potential therapeutic target, and warranting further exploration in therapeutic strategies against cholangiocarcinoma.
    Journal
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    PVT1 (Pvt1 Oncogene) • SOCS2 (Suppressor Of Cytokine Signaling 2)
    3ms
    UBE2T promotes papillary thyroid carcinoma progression by activating the JAK/STAT3 pathway via negative regulation of SOCS2. (PubMed, Semin Oncol)
    Rescue experiments and immunofluorescence confirmed UBE2T promotes oncogenesis by destabilizing SOCS2, thereby relieving its inhibition of STAT3 phosphorylation. These findings establish UBE2T as a novel regulator of PTC progression through SOCS2/JAK-STAT3 axis manipulation, providing potential therapeutic targets to mitigate metastasis and recurrence in aggressive thyroid carcinomas.
    Journal
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    SOCS2 (Suppressor Of Cytokine Signaling 2)
    4ms
    Downregulation of the Tumor Suppressor P53 Gene associated with the Progression of Clinical Staging and the Incidence of Distant Metastasis in Indonesian Colorectal Cancer. (PubMed, Korean J Gastroenterol)
    The expression of TP53 was also positively correlated with BRAF, KRAS, COL-3A1, and SOCS-2 (ρ -0.617, p<0.05; ρ -0.272, p<0.05; ρ 0.348, p<0.05; ρ 0.571, p<0.05). TP53 is downregulated in advanced clinical stages and distant metastases, demonstrating its role in aggressive nature of CRC.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • SOCS2 (Suppressor Of Cytokine Signaling 2)
    4ms
    The Role of SLC7A11 in Tumor Progression and the Regulation Mechanisms Involved in Ferroptosis. (PubMed, Cancer Manag Res)
    This study reveals how cancer cells abnormally upregulate SLC7A11 by hijacking multi-level mechanisms, gaining strong antioxidant/anti ferroptotic abilities, which are the core basis for their survival, proliferation, and resistance to treatment. This study also identified SLC7A11 as a convergence point for multiple key pathways, making it an ideal hub target for intervening in cancer and overcoming drug resistance.
    Review • Journal
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    BAP1 (BRCA1 Associated Protein 1) • SIRT3 (Sirtuin 3) • SLC7A11 (Solute Carrier Family 7 Member 11) • ATF4 (Activating Transcription Factor 4) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • SOCS2 (Suppressor Of Cytokine Signaling 2) • ALKBH5 (AlkB Homolog 5, RNA Demethylase) • DUXAP8 (Double Homeobox A Pseudogene 8) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) • METTL3 (Methyltransferase Like 3) • STEAP3 (STEAP3 Metalloreductase) • TCF12 (Transcription Factor 12)
    7ms
    Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer. (PubMed, Elife)
    Indeed, PDE1A interacted with YTHDF2, destabilized SOCS2, and activated the STAT3 pathway. Mechanistic data uncover a novel PDE1A/YTHDF2/STAT3 axis driving NSCLC metastasis and suggest potential therapeutic strategies for metastatic disease.
    Journal
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    IL6 (Interleukin 6) • SOCS2 (Suppressor Of Cytokine Signaling 2) • YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein 2)
    9ms
    Identification of key genes and signaling pathways of liver cancer and model construction for prognosis and diagnosis based on bioinformatics analysis. (PubMed, PLoS One)
    CDCA8, GRPEL2, HAVCR1, MT3, MYCN, NDRG1, PHOSPHO2, SNAPC2, SOCS2, TXNRD1 were key genes for liver cancer prognosis and diagnosis. Moreover, lowering SNAPC2 expression could improve the prognosis of liver cancer through decreasing proliferation and migration s and increasing apoptosis of cancer cell.
    Journal
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    MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • KIM1 (Kidney injury molecule 1) • NDRG1 (N-Myc Downstream Regulated 1) • SOCS2 (Suppressor Of Cytokine Signaling 2) • ANXA5 (Annexin A5) • CDCA8 (Cell Division Cycle Associated 8)
    10ms
    Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis. (PubMed, World J Gastroenterol)
    SOCS2 modulates CD4+ T function in the TME, contributing to LIHC progression. Targeting SOCS2 presents a potential therapeutic strategy for treating LIHC.
    Journal
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    CD4 (CD4 Molecule) • SOCS2 (Suppressor Of Cytokine Signaling 2)
    10ms
    Identification of a Cancer Stem Cell-Related Gene Signature in Hepatocellular Carcinoma Based on Single-Cell RNA-Seq and Bulk RNA-Seq Analysis. (PubMed, Int J Mol Sci)
    The model suggests that liver cancer progression might be driven by immune evasion independent of PD-L1 and highlights the potential of the low-risk BCSC group being sensitive to various treatments. Our findings offer a promising foundation for personalized LIHC therapy and highlight the need for further experimental validation of the roles of these CSCs in disease progression.
    Journal • Gene Signature • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • IGF1 (Insulin-like growth factor 1) • S100A9 (S100 Calcium Binding Protein A9) • SOCS2 (Suppressor Of Cytokine Signaling 2) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)
    11ms
    Modulation of Macrophages TLR4-Mediated Transcriptional Response by Lacticaseibacillus rhamnosus CRL1505 and Lactiplantibacillus plantarum CRL1506. (PubMed, Int J Mol Sci)
    This differential modulation of regulatory and inflammatory factors would allow minimal inflammatory-mediated tissue damage during the generation of the innate immune response. This work provides evidence that L. rhamnosus CRL1505 and L. plantarum CRL1506 modulate macrophages' TLR4-mediated immunotranscriptomic response, helping to improve protection against Gram-negative bacterial infections.
    Journal • IO biomarker
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • CSF2 (Colony stimulating factor 2) • SOCS1 (Suppressor Of Cytokine Signaling 1) • TLR4 (Toll Like Receptor 4) • CCL8 (C-C Motif Chemokine Ligand 8) • IL1B (Interleukin 1, beta) • IL27 (Interleukin 27) • SOCS2 (Suppressor Of Cytokine Signaling 2) • SOCS3 (Suppressor Of Cytokine Signaling 3)