^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    SNHG7 (Small Nucleolar RNA Host Gene 7)

    i
    Other names: Small Nucleolar RNA Host Gene 7, Small Nucleolar RNA Host Gene 7 (Non-Protein Coding), SNHG7, Small Nucleolar RNA Host Gene (Non-Protein Coding) 7, Non-Protein Coding RNA 61, MGC16037
    Associations

    News

    Trials
    3ms
    Progress of long-chain noncoding small nucleolar RNA host genes in thyroid cancer. (PubMed, Front Oncol)
    Overall, SNHGs may serve as molecular biomarkers and hold potential therapeutic target value. However, existing evidence is largely based on in vitro and small-sample studies, requiring further validation in clinical cohorts and functional models.
    Review • Journal
    |
    YAP1 (Yes associated protein 1) • SNHG5 (Small Nucleolar RNA Host Gene 5) • SNHG12 (Small Nucleolar RNA Host Gene 12) • SNHG14 (Small Nucleolar RNA Host Gene 14) • SNHG15 (Small Nucleolar RNA Host Gene 15) • SNHG7 (Small Nucleolar RNA Host Gene 7)
    4ms
    Silencing SOX2OT reduces viability and migration in lung cancer cells via lncRNA and protein regulation. (PubMed, Med Oncol)
    Silencing SOX2OT significantly reduces viability, migration, and survival of lung cancer cells, suggesting its potential as a therapeutic target. Further in vivo validation and rescue experiments are needed to confirm these mechanisms.
    Journal
    |
    EP300 (E1A binding protein p300) • SOX2 • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • SNHG7 (Small Nucleolar RNA Host Gene 7)
    4ms
    METTL3: A dual regulator of oral tissue regeneration and malignancy with therapeutic implications for stem cell therapy and chemoresistance. (PubMed, Sci Prog)
    It stabilizes mRNAs like c-Myc, PD-L1, and BMI1 through reader proteins (YTHDF1/IGF2BPs), driving tumor growth, metastasis, and chemoresistance (e.g., to Cisplatin and Anlotinib). We propose METTL3 as a unifying therapeutic target to advance both regenerative dentistry and precision oncology for oral diseases. Targeting METTL3 epitranscriptomics could transform future oral therapies.
    Review • Journal
    |
    PD-L1 (Programmed death ligand 1) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BMI1 (BMI1 proto-oncogene, polycomb ring finger) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • METTL3 (Methyltransferase Like 3) • RUNX2 (RUNX Family Transcription Factor 2) • SNHG7 (Small Nucleolar RNA Host Gene 7) • STC1 (Stanniocalcin 1)
    |
    cisplatin • Focus V (anlotinib)
    5ms
    Retraction Note. (PubMed, Eur Rev Med Pharmacol Sci)
    Perindopril inhibits myocardial apoptosis in mice with acute myocardial infarction through TLR4/NF-κB pathway...SNHG7 mediates cisplatin-resistance in non-small cell lung cancer by activating PI3K/AKT pathway...Natural killer cell-derived exosome-entrapped paclitaxel can enhance its anti-tumor effect...Antidiabetic drug metformin mitigates ovarian cancer SKOV3 cell growth by triggering G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signaling pathway...These articles have been retracted. The Publisher apologizes for any inconvenience this may cause.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • MIR155 (MicroRNA 155) • IGF1 (Insulin-like growth factor 1) • MMP2 (Matrix metallopeptidase 2) • TGFB1 (Transforming Growth Factor Beta 1) • MIR221 (MicroRNA 221) • MMP9 (Matrix metallopeptidase 9) • MIR139 (MicroRNA 139) • MIR490 (MicroRNA 490) • miR-185 (MicroRNA 185) • SNHG14 (Small Nucleolar RNA Host Gene 14) • SNHG7 (Small Nucleolar RNA Host Gene 7) • CD151 (CD151 Molecule)
    |
    cisplatin • paclitaxel • metformin
    8ms
    Expression of Concern. (PubMed, Eur Rev Med Pharmacol Sci)
    Downregulated long non-coding RNA TRPM2-AS inhibits cisplatin resistance of non-small cell lung cancer cells via activation of p53- p66shc pathway...PMID: 33577026. The Publisher apologizes for any inconvenience this may cause.
    Journal
    |
    IGF2 (Insulin-like growth factor 2) • MIR200B (MicroRNA 200b) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • FUS (FUS RNA Binding Protein) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • FOXO3 (Forkhead box O3) • PCNA (Proliferating cell nuclear antigen) • GAS5 (Growth Arrest Specific 5) • SMAD7 (SMAD Family Member 7) • DSCAM (DS Cell Adhesion Molecule) • HOXA-AS2 (HOXA Cluster Antisense RNA 2) • MIR29A (MicroRNA 29a) • MIR483 (MicroRNA 483) • MMP7 (Matrix metallopeptidase 7) • RBM24 (RNA Binding Motif Protein 24) • SNHG7 (Small Nucleolar RNA Host Gene 7) • TGFBR1 (Transforming Growth Factor Beta Receptor 1) • TGIF2 (TGFB Induced Factor Homeobox 2) • WTAP (WT1 Associated Protein) • XIST (X Inactive Specific Transcript) • MAGI2-AS3 (MAGI2 Antisense RNA 3)
    |
    cisplatin
    8ms
    Long non-coding RNA SNHG7 as a key driver of colorectal cancer proliferation and metastasis by inhibiting cuproptosis. (PubMed, Eur J Med Res)
    Five lncRNAs were identified as prognostic markers in CRC, with SNHG7 promoting CRC via a copper-dependent pathway. These findings provide insights for developing copper-targeted therapies for CRC patients.
    Journal
    |
    FDX1 (Ferredoxin 1) • SNHG7 (Small Nucleolar RNA Host Gene 7)
    10ms
    LncRNA SNHG7/miR-181b-5p/TLR4 Activates Inflammation And Promotes Pyroptosis Through NF-κB Signaling in Diabetic Nephropathy. (PubMed, Inflammation)
    Additionally, co-transfection of a TLR4 over-expression vector with a miR-181b-5p mimic counteracted the effects of miR-181b-5p overexpression on cell viability, LDH leakage, and the expression of inflammatory factors and pyroptosis-related molecules. In summary, SNHG7 acts as a molecular sponge for miR-181b-5p, promoting inflammation and pyroptosis in DKD, which in turn regulates TLR4 expression and the NF-κB signaling pathway.
    Journal • IO biomarker
    |
    TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • NLRC5 (NLR Family CARD Domain Containing 5) • TLR4 (Toll Like Receptor 4) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • MIR181B1 (MicroRNA 181b-1) • SNHG7 (Small Nucleolar RNA Host Gene 7)
    11ms
    Role of SNHGs in Adverse Prognostic Factors in Cervical Cancer: A Systematic Review. (PubMed, Asian Pac J Cancer Prev)
    Although further studies are needed, these data highlight the significant role of SNHGs in tumor biology and the promising potential of this class of transcripts as tools in the clinical management of cervical cancer.
    Review • Journal
    |
    GAS5 (Growth Arrest Specific 5) • SNHG16 (Small Nucleolar RNA Host Gene 16) • SNHG5 (Small Nucleolar RNA Host Gene 5) • SNHG12 (Small Nucleolar RNA Host Gene 12) • SNHG14 (Small Nucleolar RNA Host Gene 14) • SNHG17 (Small Nucleolar RNA Host Gene 17) • SNHG7 (Small Nucleolar RNA Host Gene 7)
    12ms
    Characterization of lncRNAs contributing to drug resistance in epithelial ovarian cancer. (PubMed, Med Oncol)
    To achieve this, drug-resistant subtypes of aggressive EOC cell lines, including carboplatin/paclitaxel-resistant OVCAR3 and SKOV3 lines, were developed. These results highlight the critical roles of lncRNAs in the progression and treatment response of EOC, positioning them as potential therapeutic targets and biomarkers for early diagnosis and treatment stratification. Identifying reliable lncRNA biomarkers could enable the early detection of patients at risk for developing drug resistance, thereby facilitating personalized treatment strategies to improve patient outcomes and survival rates.
    Journal
    |
    TLR8 (Toll Like Receptor 8) • PVT1 (Pvt1 Oncogene) • SNHG7 (Small Nucleolar RNA Host Gene 7) • ZFAS1 (ZNFX1 Antisense RNA 1)
    |
    carboplatin • paclitaxel
    over1year
    Correlation of SNHG7 and BGL3 expression in patients with de novo acute myeloid leukemia; novel insights into lncRNA effect in PI3K signaling context in AML pathogenesis. (PubMed, Biochem Biophys Rep)
    As the most straightforward interpretation of our results, we propose that perhaps the association between SNHG7 and BGL3 built through the interaction between Akt and PTEN may play a crucial role in the AML pathogenesis and any element of this axis could be a potential novel target for further profound treatment strategies. Nonetheless, in the context of Hematological Malignancies, particularly AML, more detailed studies are needed in this area to elucidate the precise role played by this interesting testis-specific pathway.
    Journal
    |
    PTEN (Phosphatase and tensin homolog) • SNHG7 (Small Nucleolar RNA Host Gene 7)
    over1year
    METTL3-Regulated lncRNA SNHG7 Drives MNNG-Induced Epithelial-Mesenchymal Transition in Gastric Precancerous Lesions. (PubMed, Toxics)
    In conclusion, our study provides novel insights into critical epigenetic molecular events vital to MNNG-induced gastric carcinogenesis. These findings suggest the potential therapeutic targets of METTL3 for GC treatment.
    Journal
    |
    METTL3 (Methyltransferase Like 3) • SNHG7 (Small Nucleolar RNA Host Gene 7)