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    BIOMARKER:

    SNHG1 deletion

    i
    Other names: SNHG1, Small Nucleolar RNA Host Gene 1, NCRNA00057, LINC00057, LncRNA16, UHG, Small Nucleolar RNA Host Gene 1 (Non-Protein Coding), Long Intergenic Non-Protein Coding RNA 57, Non-Protein Coding RNA 57, U22 SnoRNA Host Gene, U22 SnoRNA Host, NONHSAG008552.2, HSALNG0084672, U22HG, SNHG1
    Entrez ID:
    23642
    almost3years
    Epigenetic silencing of ZCCHC10 by the lncRNA SNHG1 promotes progression and venetoclax resistance of acute myeloid leukemia. (PubMed, Int J Oncol)
    Downregulation of ZCCHC10 decreases p53 activation, promotes cell proliferation and survival, and thereby accelerates AML progression and the acquisition of venetoclax resistance. The present study identified a SNHG1/ZCCHC10/p53 signaling axis in AML that may be a therapeutic target in this malignancy.
    Journal
    |
    TP53 (Tumor protein P53) • DNMT1 (DNA methyltransferase 1) • DNMT3B (DNA Methyltransferase 3 Beta) • SNHG1 (Small Nucleolar RNA Host Gene 1)
    |
    TP53 mutation • TP53 expression • SNHG1 deletion
    |
    Venclexta (venetoclax)