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    BIOMARKER:

    SNAI2 deletion

    i
    Other names: SNAI2, Snail Family Transcriptional Repressor 2, SLUGH 2, Snail Family Zinc Finger 2, Zinc Finger Protein SNAI2, Protein Snail Homolog 2, SLUGH1, SNAIL2, SLUG, Slug Homolog, Zinc Finger Protein (Chicken), Slug (Chicken Homolog), Zinc Finger Protein, Neural Crest Transcription Factor SLUG, Neural Crest Transcription Factor Slug, Snail Homolog 2 (Drosophila), Snail Homolog 2, SNAI2, WS2D
    Entrez ID:
    6591
    12ms
    A SNAI2/CTCF Interaction is Required for NOTCH1 Expression in Rhabdomyosarcoma. (PubMed, Mol Cell Biol)
    Thus, we have uncovered a novel mechanism by which SNAI2 and CTCF maintenance of a sub-TAD boundary promotes rather than represses NOTCH1 expression. Further, we demonstrate that SNAI2 suppression of apoptosis post-radiation is independent of SNAI2/NOTCH1 effects on self-renewal and differentiation.
    Journal
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    NOTCH1 (Notch 1) • SNAI2 (Snail Family Transcriptional Repressor 2)
    |
    NOTCH1 expression • SNAI2 deletion
    over3years
    Loss of SNAI2 in Prostate Cancer Correlates With Clinical Response to Androgen Deprivation Therapy. (PubMed, JCO Precis Oncol)
    We show that EMT characterizes acutely resistant prostate tumors and that deletion of SNAI2, a key transcriptional regulator of EMT, correlates with clinical response.
    Clinical • Journal
    |
    SNAI2 (Snail Family Transcriptional Repressor 2)
    |
    SNAI2 deletion
    |
    abiraterone acetate • bicalutamide • Firmagon (degarelix)