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    BIOMARKER:

    SMO D473H

    i
    Other names: SMO, Smoothened Frizzled Class Receptor, Smoothened Seven Transmembrane Spanning Receptor, Smoothened Frizzled Family Receptor, Frizzled Family Member 11, Smoothened Homolog, Protein Gx, SMOH, Seven Transmembrane Helix Receptor, Smoothened (Drosophila) Homolog, Smoothened Homolog (Drosophila), FZD11, CRJS, Gx
    Entrez ID:
    6608
    Related biomarkers:
    Mutation
    2years
    Polymeric micelles for cutaneous delivery of the hedgehog pathway inhibitor TAK-441: formulation development and cutaneous biodistribution in porcine and human skin. (PubMed, Int J Pharm)
    TAK-441 is a potent inhibitor of the hedgehog pathway (IC 4.4 nM) developed for the treatment of basal cell carcinoma that is active against the vismodegib-resistant Smoothened receptor D473H mutant...The cutaneous biodistribution profile demonstrated that TAK-441 was predominantly delivered to the viable epidermis and upper dermis. Delivery from the HPMC hydrogel formulation resulted in TAK-441 epidermal concentrations that were several thousand-fold higher than the IC, with almost negligible transdermal permeation, thereby decreasing the risk of systemic side effects in vivo.
    Preclinical • Journal
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    SMO D473H
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    Erivedge (vismodegib)