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BIOMARKER:

SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression

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Entrez ID:

Related biomarkers:

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PD-L1 expression (356)

PD-L1 overexpression (181)

PD-L1 underexpression (46)

PD-L1 negative (28)

HER-2 negative + PD-L1 expression (12)

HER-2 positive + PD-L1 expression (3)

HR negative + PD-L1 expression (2)

MSLN overexpression + PD-L1 overexpression (2)

PD-L1 expression + CD68 positive (2)

PD-L1 expression + HER-2 overexpression (2)

PD-L1 expression + PVR expression (2)

PD-L1 overexpression + CD8 overexpression (2)

TTF1 expression + PD-L1 expression (2)

miR-625-5p underexpression + PD-L1 overexpression (2)

CEACAM5 underexpression + MSI-H/dMMR (2)

MSI-H/dMMR + CD74 overexpression (2)

MSI-H/dMMR + HLA-B overexpression (2)

MSI-H/dMMR + HLA-DPA1 overexpression (2)

MSI-H/dMMR + HLA-DPB1 overexpression (2)

MSI-H/dMMR + HLA-DQA1 overexpression (2)

MSI-H/dMMR + HLA-DQB1 overexpression (2)

MSI-H/dMMR + HLA-DRB1 overexpression (2)

AXL overexpression + PD-L1 expression (1)

CGAS overexpression + PD-L1 overexpression (1)

CMTM4 expression + PD-L1 expression (1)

CMTM6 expression + PD-L1 expression (1)

CMTM6 overexpression + PD-L1 overexpression (1)

CXCL12 expression + PD-L1 underexpression (1)

HLA-A underexpression + PD-L1 expression (1)

HR positive + PD-L1 expression (1)

IGFBP2 overexpression + PD-L1 overexpression (1)

MHC-II overexpression + PD-L1 negative (1)

MHC-II overexpression + PD-L1 underexpression (1)

NKX2-1 expression + PD-L1 expression (1)

NR1H4 overexpression + PD‑L1 underexpression (1)

NT5E overexpression + PD-L1 expression (1)

PD-1 underexpression + PD-L1 overexpression (1)

PD-L1 expression + CD14 positive (1)

PD-L1 expression + CD47 expression (1)

PD-L1 expression + CD8 negative + GZMB negative (1)

PD-L1 expression + CD8 positive (1)

PD-L1 expression + CTLA4 expression (1)

PD-L1 expression + MTOR overexpression (1)

PD-L1 expression + REV3L overexpression (1)

PD-L1 overexpression + APOBEC3B overexpression (1)

PD-L1 overexpression + CCL5 overexpression (1)

PD-L1 overexpression + CD163 underexpression (1)

PD-L1 overexpression + ER positive (1)

PD-L1 overexpression + GZMA overexpression (1)

PD-L1 overexpression + LAG3 expression + CTAG1B expression (1)

PD-L1 overexpression + PD-L2 underexpression (1)

PD-L1 overexpression + SOX2 overexpression (1)

RBM17 expression + PD-L1 expression (1)

RET positive + PD-L1 overexpression (1)

SNX20 overexpression + PD-L1 overexpression (1)

STK11 underexpression + PD-L1 overexpression (1)

TFRC overexpression + PD-L1 underexpression (1)

TNFSF4 overexpression + PD-L1 overexpression (1)

TTF1 expression + PD-L1 overexpression (1)

SMARCA4 overexpression (1)

HER-2 negative + HR negative + PD-L1 expression (0)

PD-L1 expression + HER-2 expression (0)

PD-L1 expression + LAG3 expression (0)

PD-L1 expression + TTF1 expression (0)

TMB + PD-L1 expression (0)

PD-L1 expression (356)

PD-L1 overexpression (181)

PD-L1 underexpression (46)

PD-L1 negative (28)

HER-2 negative + PD-L1 expression (12)

HER-2 positive + PD-L1 expression (3)

HR negative + PD-L1 expression (2)

MSLN overexpression + PD-L1 overexpression (2)

PD-L1 expression + CD68 positive (2)

PD-L1 expression + HER-2 overexpression (2)

PD-L1 expression + PVR expression (2)

PD-L1 overexpression + CD8 overexpression (2)

TTF1 expression + PD-L1 expression (2)

miR-625-5p underexpression + PD-L1 overexpression (2)

CEACAM5 underexpression + MSI-H/dMMR (2)

MSI-H/dMMR + CD74 overexpression (2)

MSI-H/dMMR + HLA-B overexpression (2)

MSI-H/dMMR + HLA-DPA1 overexpression (2)

MSI-H/dMMR + HLA-DPB1 overexpression (2)

MSI-H/dMMR + HLA-DQA1 overexpression (2)

MSI-H/dMMR + HLA-DQB1 overexpression (2)

MSI-H/dMMR + HLA-DRB1 overexpression (2)

AXL overexpression + PD-L1 expression (1)

CGAS overexpression + PD-L1 overexpression (1)

CMTM4 expression + PD-L1 expression (1)

CMTM6 expression + PD-L1 expression (1)

CMTM6 overexpression + PD-L1 overexpression (1)

CXCL12 expression + PD-L1 underexpression (1)

HLA-A underexpression + PD-L1 expression (1)

HR positive + PD-L1 expression (1)

IGFBP2 overexpression + PD-L1 overexpression (1)

MHC-II overexpression + PD-L1 negative (1)

MHC-II overexpression + PD-L1 underexpression (1)

NKX2-1 expression + PD-L1 expression (1)

NR1H4 overexpression + PD‑L1 underexpression (1)

NT5E overexpression + PD-L1 expression (1)

PD-1 underexpression + PD-L1 overexpression (1)

PD-L1 expression + CD14 positive (1)

PD-L1 expression + CD47 expression (1)

PD-L1 expression + CD8 negative + GZMB negative (1)

PD-L1 expression + CD8 positive (1)

PD-L1 expression + CTLA4 expression (1)

PD-L1 expression + MTOR overexpression (1)

PD-L1 expression + REV3L overexpression (1)

PD-L1 overexpression + APOBEC3B overexpression (1)

PD-L1 overexpression + CCL5 overexpression (1)

PD-L1 overexpression + CD163 underexpression (1)

PD-L1 overexpression + ER positive (1)

PD-L1 overexpression + GZMA overexpression (1)

PD-L1 overexpression + LAG3 expression + CTAG1B expression (1)

PD-L1 overexpression + PD-L2 underexpression (1)

PD-L1 overexpression + SOX2 overexpression (1)

RBM17 expression + PD-L1 expression (1)

RET positive + PD-L1 overexpression (1)

SNX20 overexpression + PD-L1 overexpression (1)

STK11 underexpression + PD-L1 overexpression (1)

TFRC overexpression + PD-L1 underexpression (1)

TNFSF4 overexpression + PD-L1 overexpression (1)

TTF1 expression + PD-L1 overexpression (1)

SMARCA4 overexpression (1)

HER-2 negative + HR negative + PD-L1 expression (0)

PD-L1 expression + HER-2 expression (0)

PD-L1 expression + LAG3 expression (0)

PD-L1 expression + TTF1 expression (0)

TMB + PD-L1 expression (0)

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almost2years

SMARCA4-deficient Undifferentiated Lung Carcinoma with Additional Microsatellite Instability Mixed Response to Pembrolizumab Followed by Hyperprogression – A Cautionary Tale Highlighting the Pitfalls to Tumor Agnostic Drug Approvals (IASLC-TTLC 2023)

Initial MDTB recommendations including definitive chemo-RT with subsequent consolidation durvalumab were not ideal due large primary tumor and low performance status. Extrapolating from other tumor types’ outcome data may not translate as optimistically to NSCLC. Further review of population-based data on dMMR/MSI-H NSCLC and SMARCA-4UT is warranted to elucidate outcomes of PD-1 inhibitor treatment on these tumor types

almost 2 years ago

Microsatellite instability • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker • Pan tumor

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PD-L1 (Programmed death ligand 1) • MSI (Microsatellite instability) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4)

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MSI-H/dMMR • PD-L1 underexpression • PD-1-L • PD-L1-L • SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression

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Keytruda (pembrolizumab) • Imfinzi (durvalumab)