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    BIOMARKER:

    SMAD4 overexpression

    i
    Other names: HSMAD4, Mothers Against DPP Homolog 4, SMAD, Mothers Against DPP Homolog 4, Deleted In Pancreatic Carcinoma Locus 4, SMAD, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic, Drosophila, Homolog Of, 4, MADH4, MAD, Mothers Against Decapentaplegic Homolog 4, Mothers Against Decapentaplegic Homolog 4, MAD Homolog 4, SMAD4, SMAD Family Member 4, Deletion Target In Pancreatic Carcinoma 4
    Entrez ID:
    4089
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    Associations

    News

    Trials
    2ms
    Smad4 regulates TGF-β1-mediated hedgehog activation to promote epithelial-to-mesenchymal transition in pancreatic cancer cells by suppressing Gli1 activity. (PubMed, Comput Struct Biotechnol J)
    Inhibition of hedgehog with cyclopamine effectively antagonized TGF-β1-induced EMT, thereby suggesting that the hedgehog signaling may act as a downstream cascade signaling of TGF-β1...Importantly, Gli1 activity was upregulated by Smad4 knockdown in PANC-1 cells and downregulated by Smad4 overexpression in BxPc-3 cells, indicating that Gli1 may be a negative target protein downstream of Smad4. Thus, Smad4 regulates TGF-β1-mediated hedgehog activation to promote EMT in PCCs by suppressing Gli1 activity.
    Journal
    |
    SMAD4 (SMAD family member 4) • GLI1 (GLI Family Zinc Finger 1) • TGFB1 (Transforming Growth Factor Beta 1) • GLI3 (GLI Family Zinc Finger 3) • SMAD2 (SMAD Family Member 2)
    |
    GLI1 expression • SMAD4 expression • SMAD4 overexpression
    |
    cyclopamine
    8ms
    S100A2 induces epithelial-mesenchymal transition and metastasis in pancreatic cancer by coordinating transforming growth factor β signaling in SMAD4-dependent manner. (PubMed, Cell Death Discov)
    In conclusion, the S100A2/SMAD4 axis modulates EMT to accelerate PDAC development. Our results supplement and enrich the understanding of the pathogenesis underlying PDAC and provide a new theoretical basis and strategy targeting S100A2 for the diagnosis and treatment of PDAC.
    Journal
    |
    SMAD4 (SMAD family member 4)
    |
    SMAD4 expression • SMAD4 overexpression
    over2years
    Downregulation of Smad4 expression confers chemoresistance against imatinib mesylate to chronic myeloid leukemia K562 cells. (PubMed, Hematology)
    In addition, Smad4 expression was inversely correlated with laminin subunit gamma 1 (LAMC1) expression. The upregulation or downregulation of LAMC1 expression partially abolished the effect of Smad4 overexpression or silencing on the IM resistance of CML cells. The downregulation of Smad4 expression might induce drug resistance in CML cells and displayed a possible mechanism through which Smad4 modulates CML cell survival and apoptosis upon IM treatment.
    Journal
    |
    SMAD4 (SMAD family member 4) • TGFB1 (Transforming Growth Factor Beta 1) • LAMC1 (Laminin Subunit Gamma 1)
    |
    SMAD4 expression • SMAD4 overexpression
    |
    imatinib