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    BIOMARKER:

    SLFN11 elevation

    i
    Other names: SLFN11, Schlafen Family Member 11,SLFN8/9
    Entrez ID:
    91607
    Related biomarkers:
    Expression
    1year
    Modulation of SLFN11 induces changes in DNA Damage response in breast cancer. (PubMed, Cancer Cell Int)
    To our knowledge this is the first report of the stable non-lethal increase of SLFN11 expression in a cancer cell line. Our results show that induction of SLFN11 expression can enhance DDA and DDR sensitivity in breast cancer cells and dCas9 systems may represent a novel approach to increase SLFN11 and achieve higher sensitivity to chemotherapeutic agents, improving outcome or decreasing required drug concentrations. SLFN11-targeting therapies might be explored pre-clinically to develop personalized approaches.
    Journal • PARP Biomarker
    |
    IFNG (Interferon, gamma) • SLFN11 (Schlafen Family Member 11)
    |
    SLFN11 expression • IFNG expression • SLFN11 elevation
    |
    Lynparza (olaparib) • cisplatin • decitabine • epirubicin