SLCO1B3 (Solute carrier organic anion transporter family member 1B3)

It was stated that the AHR, EPHX1, GSTP1, and SLC25A32 did not correlate in healthy intestinal tissue whereas AHCY, ALDH1A1, NNMT, GSTM4, UGT2B17, and SLCO1B3 did not correlate in CRC. The disturbed transcriptional activity of genes related to the biotransformation process at all stages of CRC suggests that this may be the cause of its occurrence; the genes ought to be taken into account in preventive strategies and the treatment of patients.

Single-cell sequencing data showed that LUAD patients exhibited an immunosuppressive TME phenotype, which was exacerbated by high TIMP1 expression in epithelial cells, promoting Treg cell activity. The 7-gene ARG prognostic model established in this study shows promising potential as a clinically applicable tool for decision-making.

Furthermore, we found that inhibiting the apoptosis-related gene CTTN suppresses the anti-apoptotic capacity of HNSCC. Results from HNSCC-PDOs suggest that CTTN may represent a key target for HNSCC invasion and treatment.

FNH/FNH-like lesions with hepatobiliary phase hypointensity, the characteristic finding of hyperintensity relative to intrahepatic vessels distinguished them from similarly presenting HCCs. Careful evaluation of this specific imaging feature might have potentially avoided the need for invasive treatment or biopsy in these diagnostically challenging cases.

Quantitative PCR analysis of 18 patients' BC tissue samples revealed variable expression of a number of SLCO transporters, regardless of patients having been treated with or without endocrine therapy prior to tumour excision. Proliferation and gene expression studies were conducted on the cell lines following exposure to β-estradiol, which stimulated cell proliferation in MCF-7 cells, as well as causing a significant increase in SLCO4C1 gene expression.

Our results strongly suggest the presence of a candidate gene signature comprising ATP1B3 and SLCO1B3 that holds predictive value for chemoradiotherapy response in cervical cancer.

In HCC patients, the downregulation of SLCO1B1, SLCO1B3, and SLCO2B1 expression has been observed. SLCO genes such as SLCO1B1, SLCO1B3, and SLCO2B1 expression levels may also serve as prognostic predictive markers in HCC patients.

DAC promoted OATP1B3 expression by inhibiting SLCO1B3 methylation, thereby enhancing HCC sensitivity to sorafenib. These findings may offer novel therapeutic strategies for the clinical management of HCC.

The co-therapy with HCSI alleviated the intestinal toxicity induced by CPT-11 and exerted an enhanced anti-CRC effect. The detoxifying mechanism may be related to the increased expression of UGT1A1 and OATP1B3 by HCSI and its bufadienolides components. The findings of this study may serve as a theoretical insights and strategies to improve CRC patient outcomes. Please cite this article as: Jiang B, Meng ZY, Hu YJ, Chen JJ, Zong L, Xu LY, Zhang XQ, Zhang JX, Han YL. Huachansu injection enhances anti-colorectal cancer efficacy of irinotecan and alleviates its induced intestinal toxicity through upregulating UGT1A1-OATP1B3 expression in vitro and in vivo. J Integr Med. 2025; Epub ahead of print.

Hepatic IPTs are typically composed of lymphoplasmacytic and fibroblastic accumulations. In the present case, OATP1B3 expression was relatively decreased without such accumulation according to IgG4-related inflammation, suggesting that IgG4-related inflammation may regulate OATP1B3 expression.

SLC variants can be predictive signals of imatinib responses among CML; Asian patients should be paid attention during the treatment.

These results help to build a better mechanistic understanding of the disposition of androgen sulfates in the human body. Additionally, this data may be used to assess the feasibility of androgen sulfates as additional biomarkers in doping detection.