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    BIOMARKER:

    SLCO1B3 334T

    i
    Other names: SLCO1B3, Solute carrier organic anion transporter family member 1B3, LST3, HBLRR, LST-2, OATP8, OATP-8, OATP1B3, SLC21A8, LST-3TM13
    Entrez ID:
    28234
    Related biomarkers:
    Expression
    Mutation
    over2years
    Determination of the Cut-off Value for Imatinib Plasma Levels Linked to Occurrence of Bone Pain in CML Patients. (PubMed, Drug Des Devel Ther)
    Higher peak and trough plasma concentrations of imatinib are linked with the risk of the occurrence of bone pain as a side effect of imatinib. Monitoring plasma concentrations of imatinib is useful to predict the bone pain of imatinib and to support quality of life in patients with CML.
    Journal
    |
    SLCO1B3 (Solute carrier organic anion transporter family member 1B3)
    |
    SLCO1B3 334T
    |
    imatinib
    over2years
    Impacts of SNPs on adverse events and trough concentration of imatinib in patients with gastrointestinal stromal tumors. (PubMed, Drug Metab Pharmacokinet)
    Of them, SLCO1B3 334T>G and SLCO1A2 -1032G>A made significant contributions to the individual variability of C by multivariate regression analysis. Genetic variations in ABCG2, SLCO1B3, and SLCO1A2 may play important roles in the safety and pharmacokinetics of imatinib in Japanese patients with GIST, although a replication study is necessary for validation.
    Journal • Adverse events
    |
    ABCG2 (ATP Binding Cassette Subfamily G Member 2) • SLCO1B3 (Solute carrier organic anion transporter family member 1B3)
    |
    SLCO1B3 334T
    |
    imatinib
    over3years
    Association of SLC22A1,SLCO1B3 Drug Transporter Polymorphisms and Smoking with Disease Risk and Cytogenetic Response to Imatinib in Patients with Chronic Myeloid Leukemia. (PubMed, Lab Med)
    Our study results suggest the influence of SLC22A1 and SLCO1B3 polymorphisms and the interaction of smoking on CML development and IM response.
    Clinical • Journal
    |
    SLCO1B3 (Solute carrier organic anion transporter family member 1B3) • SLC22A1 (Solute Carrier Family 22 Member 1)
    |
    SLC22A1 1222AG • SLCO1B3 334T • SLCO1B3 334TT
    |
    imatinib