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    BIOMARKER:

    SLCO1B1 rs2306283

    i
    Other names: SLCO1B1, Solute Carrier Organic Anion Transporter Family Member 1B1, OATP1B1, OATP-C, LST-1, SLC21A6, Solute Carrier Family 21 (Organic Anion Transporter), Member 6, Sodium-Independent Organic Anion-Transporting Polypeptide 2, Liver-Specific Organic Anion Transporter 1, OATP-2, OATP2, OATPC, LST1, Solute Carrier Organic Anion Transporter Family, Member 1B1, Solute Carrier Family 21 Member 6, HBLRR
    Entrez ID:
    10599
    over2years
    Single-nucleotide polymorphisms and the effectiveness of taxane-based chemotherapy in premenopausal breast cancer: a population-based cohort study in Denmark. (PubMed, Breast Cancer Res Treat)
    Docetaxel effectiveness was influenced by SNPs in GSTP1, CYP3A, and SLCO1B1 in premenopausal women with non-distant metastatic breast cancer, likely related to altered docetaxel pharmacokinetics. These SNPs may help determine individual benefit from taxane-based chemotherapy.
    Journal
    |
    GSTP1 (Glutathione S-transferase pi 1)
    |
    GSTP1 rs1138272 • SLCO1B1 rs2306283
    |
    docetaxel • cyclophosphamide