^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    SLC35C1 (Solute Carrier Family 35 Member C1)

    i
    Other names: SLC35C1, Solute Carrier Family 35 Member C1, FUCT1, GDP-Fucose Transporter 1, Solute Carrier Family 35 (GDP-Fucose Transporter), Member C1, FLJ11320, Solute Carrier Family 35, Member C1, CDG2C
    Associations

    News

    Trials
    1year
    Machine Learning Enabled Prediction of Biologically Relevant Gene Expression Using CT-Based Radiomic Features in Non-Small Cell Lung Cancer. (PubMed, Cancer Med)
    The successful integration of heterogeneous radiogenomic datasets underscores the potential of imaging biomarkers in uncovering NSCLC biological processes through gene expression profiles.
    Retrospective data • Journal • Machine learning
    |
    BCL2L1 (BCL2-like 1) • MAPK1 (Mitogen-activated protein kinase 1) • SLC35C1 (Solute Carrier Family 35 Member C1)
    2years
    A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of regulatory T cells in cancer. (PubMed, Cancer Immunol Res)
    Furthermore, an enrichment of a FucoLOW signature, mainly derived from Tregs, correlated with better prognosis and response to immune checkpoint blockade in melanoma patients. In conclusion, Slc35c1-dependent fucosylation is able to regulate the suppressive function of Tregs, and measuring its expression in Tregs might pave the way towards a useful biomarker model for cancer patients.
    Journal
    |
    FOXP3 (Forkhead Box P3) • SLC35C1 (Solute Carrier Family 35 Member C1)
    |
    FOXP3 expression
    over2years
    Ablation of the GDP-fucose transporter suppresses lung cancer cell proliferation and migration by reducing expression of PD-L1. (PubMed, J Cancer)
    The down-regulated expression of PD-L1 leads to a decline in lung cancer cell proliferation and migration. These results suggest that fucosylation partially influences LUAD tumorigenesis by regulating PD-L1 expression.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • SLC35C1 (Solute Carrier Family 35 Member C1)
    |
    PD-L1 expression