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    GENE:

    SLC31A2 (Solute Carrier Family 31 Member 2)

    i
    Other names: SLC31A2, Solute Carrier Family 31 Member 2, HCTR2, CTR2, Copper Transporter 2, COPT2, Solute Carrier Family 31 (Copper Transporter), Member 2, Probable Low Affinity Copper Uptake Protein 2, Solute Carrier Family 31 (Copper Transporters), Member 2
    Associations

    News

    Trials
    2ms
    Tumor immune microenvironment score predicts efficacy of immune checkpoint inhibitors-based regimens in advanced non-small cell lung cancer. (PubMed, J Transl Med)
    PIE represents a clinically relevant, transcriptome-based predictive model for evaluating the benefit of ICI treatment in advanced NSCLC. With further prospective validation, PIE may facilitate personalized patient selection and guide the development of novel strategies to overcome primary resistance.
    Journal • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • IL7R (Interleukin 7 Receptor) • NCAM1 (Neural cell adhesion molecule 1) • KRT14 (Keratin 14) • SLC31A2 (Solute Carrier Family 31 Member 2) • SLC4A1 (Solute Carrier Family 4 Member 1)
    almost2years
    Exploring the Role of DNA Methylation Located in Cuproptosis-Related Genes: Implications for Prognosis and Immune Landscape in Hepatocellular Carcinoma. (PubMed, Front Biosci (Landmark Ed))
    Our findings reveal possible mechanisms of CRG-located DNA-methylation on the advancement of HCC and offers new perspectives for prognostic assessment and treatment options.
    Journal • Epigenetic controller
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    SLC31A2 (Solute Carrier Family 31 Member 2)
    |
    SLC31A2 expression
    2years
    A genome-wide association study of contralateral breast cancer in the Women's Environmental Cancer and Radiation Epidemiology Study. (PubMed, Breast Cancer Res)
    The present GWAS identified two previously unreported loci with suggestive genome-wide significance. We also confirm that an elevated risk of CBC is associated with a comprehensive breast cancer susceptibility PRS that is independent of known breast cancer risk factors. These findings advance our understanding of genetic risk factors involved in CBC etiology.
    Journal
    |
    SLC31A2 (Solute Carrier Family 31 Member 2) • TRIM31 (Tripartite Motif Containing 31)
    over2years
    Validation of a Novel Cuproptosis-Related Prognostic Gene Marker and Differential Expression Associated with Lung Adenocarcinoma. (PubMed, Curr Issues Mol Biol)
    DβH, UBE2D3, SOD1, UBE2D1, and LOXL2 are potential candidates implicated in LUAD and can be further explored for their application as diagnostic, prognostic, and therapeutic biomarkers for LUAD.
    Journal • IO biomarker
    |
    CD8 (cluster of differentiation 8) • MAP2K2 (Mitogen-activated protein kinase kinase 2) • CD4 (CD4 Molecule) • CCL8 (C-C Motif Chemokine Ligand 8) • LOXL2 (Lysyl Oxidase Like 2) • MIR181C (MicroRNA 181c) • MIR29A (MicroRNA 29a) • SLC31A2 (Solute Carrier Family 31 Member 2) • ULK2 (Unc-51 Like Autophagy Activating Kinase 2) • UBE2D3 (Ubiquitin Conjugating Enzyme E2 D3)
    almost3years
    Systematic pan-cancer analysis identifies SLC31A1 as a biomarker in multiple tumor types. (PubMed, BMC Med Genomics)
    These findings demonstrated that SLC31A1 is associated with multiple tumor types and disease prognosis. SLC31A1 may be a potential key biomarker and therapeutic target in cancers.
    Journal • Pan tumor
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    PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • SLC31A1 (Solute Carrier Family 31 Member 1) • SLC31A2 (Solute Carrier Family 31 Member 2)
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    PIK3CA mutation