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SLC31A1 (Solute Carrier Family 31 Member 1)

News alerts, weekly reports and conference planners

ZNF384-regulated SLC31A1 expression promotes tumor proliferation and invasion in breast cancer. (PubMed, Mol Cell Biochem)

SLC31A1 plays a crucial role in the proliferation and invasion of breast cancer cells, and its expression is regulated by ZNF384. These findings highlight SLC31A1 as a potential therapeutic target and suggest that modulation of copper metabolism may offer novel strategies for breast cancer treatment.

1 month ago

Journal

SLC31A1 (Solute Carrier Family 31 Member 1) • ZNF384 (Zinc Finger Protein 384)

2ms

Tumor CTR1 and serum copper dynamics reveal a coordinated copper axis linked to high-grade triple-negative breast cancer biology. (PubMed, medRxiv)

Parallel CTR1 upregulation in tumors and systemic copper elevation post-therapy suggest a coordinated copper mobilization program in high-grade TNBC. These integrated retrospective and prospective findings link copper transport to therapy response and tumor aggressiveness, highlighting copper biology as a potential therapeutic axis in breast cancer.

2 months ago

Journal

SLC31A1 (Solute Carrier Family 31 Member 1)

2ms

A stimuli-responsive cuproptosis switch boosts persistent immunotherapy for tumor eradication. (PubMed, Biomaterials)

As a result, complete elimination of primary and distant tumors in mice was achieved at low doses without side effects. The US-sensitized cuproptosis switch may provide opportunities for elimination of local residual tumors and abscopal metastatic foci for final tumor eradication.

2 months ago

Journal • IO biomarker

ATP7A (ATPase Copper Transporting Alpha) • SLC31A1 (Solute Carrier Family 31 Member 1)

2ms

YTHDC2 inhibits the resistance of lung cancer to EGFR-TKI through cuproptosis. (PubMed, Oncogene)

Additionally, we found that the copper ionophore disulfiram (DSF) overcame osimertinib resistance by augmenting YTHDC2 expression. Collectively, our findings elucidate a novel YTHDC2-SLC31A1-cuproptosis axis as a key mechanism underlying EGFR-TKI resistance and propose new therapeutic strategies for its reversal.

2 months ago

Journal

SLC31A1 (Solute Carrier Family 31 Member 1) • YTHDC2 (YTH N6-Methyladenosine RNA Binding Protein C2)

Tagrisso (osimertinib)

3ms

Cuproptosis Contributes to Cisplatin-Induced Nephrotoxicity: Insights into Thymol's Potential Inhibitory and Protective Effects. (PubMed, Pharmaceuticals (Basel))

This further supports the inhibitory effect of thymol on cuproptosis, which underlies its protective properties. This study illustrates that cuproptosis and oxidative stress play crucial roles in the development and progression of cisplatin-induced nephrotoxicity, and the protective activity of thymol is attributed, at least in part, to blunting these mechanisms.

3 months ago

Journal

ATP7A (ATPase Copper Transporting Alpha) • DLAT (Dihydrolipoamide S-Acetyltransferase) • FDX1 (Ferredoxin 1) • LIAS (Lipoic Acid Synthetase) • SLC31A1 (Solute Carrier Family 31 Member 1)

3ms

Towards Personalized Chemotherapy in Gastrointestinal Cancers: Prospective Analysis of Pharmacogenetic Variants in a Russian Cohort. (PubMed, Genes (Basel))

Several clinically relevant variants were identified: DPYD rs2297595 occurred more frequently than in European cohorts, and UGT1A1 rs8175347 was observed at a higher prevalence, underscoring the potential risk of irinotecan-related neutropenia and diarrhea... This study provides the first comprehensive description of pharmacogenetic polymorphisms in a Russian cohort of patients with gastrointestinal cancers. Our findings confirm the clinical importance of DPYD and UGT1A1 testing and highlight additional variants of potential interest.

3 months ago

Observational data • Journal

ERCC1 (Excision repair cross-complementation group 1) • UGT1A1 (UDP glucuronosyltransferase family 1 member A1) • GSTP1 (Glutathione S-transferase pi 1) • TYMS (Thymidylate Synthetase) • MTHFR (Methylenetetrahydrofolate Reductase) • XPC (XPC Complex Subunit, DNA Damage Recognition And Repair Factor) • CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) • DPYD (Dihydropyrimidine Dehydrogenase) • SLC31A1 (Solute Carrier Family 31 Member 1)

irinotecan

3ms

Cuproptosis-driven astrocyte reactivity exacerbates experimental cerebral malaria pathogenesis. (PubMed, Parasit Vectors)

These findings establish that cuproptosis exacerbates ECM pathogenesis by promoting astrocyte reactivity, highlighting copper homeostasis modulation as a potential therapeutic strategy for CM.

3 months ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • ATP7A (ATPase Copper Transporting Alpha) • DLAT (Dihydrolipoamide S-Acetyltransferase) • DLST (Dihydrolipoamide S-Succinyltransferase) • FDX1 (Ferredoxin 1) • GFAP (Glial Fibrillary Acidic Protein) • SLC31A1 (Solute Carrier Family 31 Member 1)

3ms

Novel Ce/Cu-modified black ceramics disrupted mitochondrial dysfunction and tricarboxylic acid cycle to induce cuproptosis in osteosarcoma cells. (PubMed, Biomater Adv)

Our research confirmed that Ce/Cu-modified black ceramics have superior anti-tumor effects and potential mechanisms, confirming the clinical potential of Ce/Cu-modified black ceramics in cancer treatment and providing theoretical basis for the clinical translation.

3 months ago

Journal

ATP7A (ATPase Copper Transporting Alpha) • DLAT (Dihydrolipoamide S-Acetyltransferase) • LIAS (Lipoic Acid Synthetase) • SLC31A1 (Solute Carrier Family 31 Member 1)

3ms

Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis. (PubMed, Open Med (Wars))

ROC analysis demonstrated strong predictive accuracy for SLC31A1 in prognosis assessment (AUC = 0.859). High serum SLC31A1 expression correlates with aggressive clinicopathological features and independently predicts adverse outcomes in PTC patients, suggesting its potential as a prognostic biomarker for clinical stratification.

3 months ago

Journal

SLC31A1 (Solute Carrier Family 31 Member 1)

4ms

Copper transporter 1 contributes to the progression of cholangiocarcinoma. (PubMed, Biochim Biophys Acta Gen Subj)

SLC31A1 promotes cholangiocarcinoma progression by maintaining copper homeostasis, mitochondrial integrity, and redox balance. These findings suggest that SLC31A1 may serve as a potential prognostic biomarker and a candidate therapeutic target.

4 months ago

Journal

SLC31A1 (Solute Carrier Family 31 Member 1)

4ms

SIRT7 deficiency promoted cuproptosis-mediated mitochondrial dysfunction and inhibited malignant development of cervical cancer. (PubMed, Arch Biochem Biophys)

SIRT7 was recognized as an oncogene in cervical cancer, which boosted cervical cancer cell proliferation and invasion, lowered intracellular copper levels, and prevented cuproptosis. SIRT7 downregulation triggered cuproptosis, inhibiting tumor cell growth.

4 months ago

Journal

DLAT (Dihydrolipoamide S-Acetyltransferase) • FDX1 (Ferredoxin 1) • LIAS (Lipoic Acid Synthetase) • SIRT7 (Sirtuin 7) • SLC31A1 (Solute Carrier Family 31 Member 1)

4ms

Dynamic profiles of 25 serum biomarkers in acute myocardial infarction. (PubMed, Front Cardiovasc Med)

They returned to baseline levels at 12 h and 2 h respectively, followed by rapid decreases again. This study is the first to systematically characterize the dynamic profiles of 25 serum biomarkers following AMI in rats, revealing that: (1) IL-1β, S100A8, BNP, SLC31A1 and Cys may serve as an ultra-early (1 h) diagnostic panel (increase of over 70% at 1 h); (2) the delayed elevation of α-SMA and CXCL16 may be associated with the initiation of myocardial repair; (3) the suppression of Lp-α and D2D might reflect compensatory protective mechanisms.

4 months ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • S100A8 (S100 Calcium Binding Protein A8) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • CCL2 (Chemokine (C-C motif) ligand 2) • MMP9 (Matrix metallopeptidase 9) • CCR2 (C-C Motif Chemokine Receptor 2) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • ANPEP (Alanyl Aminopeptidase, Membrane) • CRP (C-reactive protein) • CTGF (Connective tissue growth factor) • CXCL16 (C-X-C Motif Chemokine Ligand 16) • DRD2 (Dopamine Receptor D2) • SLC31A1 (Solute Carrier Family 31 Member 1)