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    GENE:

    SLC25A17 (Solute Carrier Family 25 Member 17)

    i
    Other names: SLC25A17, Solute Carrier Family 25 Member 17, PMP34, Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein, 34kDa), Member 17, Peroxisomal Membrane Protein PMP34, Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein, 34kD), Member 17, Peroxisomal Membrane Protein (34kD), 34 KDa Peroxisomal Membrane Protein
    Associations

    News

    Trials
    6ms
    USF2 regulates the JAK2/STAT3 pathway through PEX3-mediated SLC25A17 upregulation to affect lipid metabolism and promote the progression of lung adenocarcinoma. (PubMed, Toxicol Appl Pharmacol)
    Results showed that USF2 knockdown inhibits abnormal lipid metabolism and tumor growth in xenografted mice. In conclusion, our study demonstrates that USF2 overexpression enhances SLC25A17-mediated JAK2/STAT3 signaling by promoting PEX3 transcriptional activation, thereby exacerbating abnormal lipid metabolism in A549 cells and accelerating LUAD progression.
    Journal
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    FASN (Fatty acid synthase) • ACOX1 (Acyl-CoA Oxidase 1) • SLC25A17 (Solute Carrier Family 25 Member 17)
    almost2years
    Identification of ACAA1 and HADHB as potential prognostic biomarkers based on a novel fatty acid oxidation-related gene model in head and neck squamous cell carcinoma: A retrospective study. (PubMed, Arch Oral Biol)
    The gene prognostic model has illustrated promising capability in predicting the prognosis, and ACAA1 and HADHB might serve as potential therapeutic biomarkers for HNSCC patients.
    Retrospective data • Journal
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    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • IRS2 (Insulin receptor substrate 2) • ACACB (Acetyl-CoA Carboxylase Beta) • SLC25A17 (Solute Carrier Family 25 Member 17)
    almost2years
    SLC25A17 inhibits autophagy to promote triple-negative breast cancer tumorigenesis by ROS-mediated JAK2/STAT3 signaling pathway. (PubMed, Cancer Cell Int)
    SLC25A17 up-regulation may be a critical factor driving TNBC progression by modulating ROS production and autophagy. Consequently, targeting SLC25A17 could be an effective therapeutic strategy against TNBC.
    Journal
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    SLC25A17 (Solute Carrier Family 25 Member 17)
    over2years
    An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD. (PubMed, Exp Cell Res)
    These results indicate that reduced expression of SLC25A3 in fatty liver contributes to electron leak from mitochondria by limiting Cu availability, rendering hepatocytes more susceptible to oxidative stress. This study provides evidence that SLC25A3 is a novel risk factor for developing NASH.
    Journal
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    SLC25A17 (Solute Carrier Family 25 Member 17) • SLC25A3 (Solute Carrier Family 25 Member 3)
    over2years
    Multiomics data analyses to identify SLC25A17 as a novel biomarker to predict the prognosis and immune microenvironment in head and neck squamous cell carcinoma. (PubMed, BMC Bioinformatics)
    SLC25A17 can effectively predict the prognosis of HNSCC patients and could be a precise individual-targeted indicator for the treatment of HNSCC patients.
    Journal • IO biomarker
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    SLC25A17 (Solute Carrier Family 25 Member 17)