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    DRUG:

    SLC-149

    i
    Other names: SLC-149
    Associations

    News

    Trials
    Company:
    SignalChem Lifesci
    Drug class:
    Carbonic anhydrase IX inhibitor
    Related drugs:
    Associations

    News

    Trials
    over3years
    Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer. (PubMed, J Med Chem)
    We show that SLC-149 is a better inhibitor than acetazolamide against CAIX. However, SLC-149 has little effect on cytotoxicity, and high concentrations are required to inhibit cell growth, migration, and invasion. These data support the hypothesis that CAIX activity, shown to be important in regulating extracellular pH, does not underlie its ability to control cell growth.
    Journal
    |
    CA9 (Carbonic anhydrase 9)
    |
    CA9 expression
    |
    SLC-149 • acetazolamide