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    BIOMARKER:

    SLBP expression

    i
    Other names: SLBP, Stem-Loop Binding Protein, HBP, Stem-Loop (Histone) Binding Protein, Histone RNA Hairpin-Binding Protein, Histone Binding Protein, Histone Stem-Loop Binding Protein, Histone Stem-Loop-Binding Protein, Hairpin Binding Protein Histone
    Entrez ID:
    7884
    Related biomarkers:
    Expression
    2years
    Downregulation of Stem-loop binding protein by nicotine via α7-nicotinic acetylcholine receptor and its role in nicotine-induced cell transformation. (PubMed, Toxicol Sci)
    Importantly, nicotine-induced anchorage-independent cell growth is attenuated by inhibition of α7-nAChR and is rescued by overexpression of SLBP. We propose that the SLBP depletion and polyadenylation of canonical histone mRNAs via activation of α7-nAChR and a series of downstream signal transduction pathways, are critical for nicotine-induced cell transformation and potential carcinogenesis.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • SLBP (Stem-Loop Binding Protein)
    |
    SLBP expression
    3years
    DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP. (PubMed, Cancer Gene Ther)
    Taken together, DRAIC sponged miR-432-5p to enhance SLBP expression, by which malignant behaviors of BRCA cells were promoted. Our findings may help to provide a promising therapeutic target for BRCA patients.
    Journal • BRCA Biomarker
    |
    BRCA (Breast cancer early onset) • SLBP (Stem-Loop Binding Protein)
    |
    SLBP expression