Skin Cancer

Analysis of human SCC specimens revealed elevated 4E-BP1 phosphorylation together with increased proliferative and angiogenic markers and activation of the mTOR signaling pathway, mirroring molecular features observed in 4E-BP1-deficient tumors. Collectively, these findings establish 4E-BP1 as a tumor suppressor in skin carcinogenesis that constrains both proliferative and angiogenic processes, underscoring the contribution of dysregulated translation to SCC development.

P=N/A, N=5, Recruiting, Emory University | Not yet recruiting --> Recruiting

To treat the infection and skin carcinoma, antibiotics and plastic surgery were employed. The identified XPC variant has not been previously reported in Chinese or global populations, expanding the mutational spectrum of this gene and providing valuable data for genetic counseling of affected families.

Quantitative three-dimensional imaging approaches are also applied to craniofacial surgery, where cone-beam computed tomography-based analyses identify determinants of lip cant and facial midline correction following bimaxillary surgery. A conceptual synthesis places living systems and learning systems within shared theoretical frameworks, highlighting the convergence of physics, information theory, and artificial intelligence in understanding biological organization.

Histopathologic evaluation revealed characteristic features of invasive melanoma, including atypical melanocytic nests, pagetoid spread, cytologic atypia, and architectural disorder. Overall, ACSL4 expression was significantly upregulated in primary cutaneous melanoma compared with normal skin, particularly within dermal atypical melanocytic tumor cells, suggesting that ACSL4 may contribute to melanoma biology through lipid metabolic pathways and may represent a potential biomarker of tumor aggressiveness, warranting further investigation into its diagnostic and prognostic relevance.

The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 17: 6526-6532, 2018; DOI: 10.3892/mmr.2018.8663].

Rarer alterations in KIT and RTKs also define actionable subsets. This review synthesizes recent mechanistic insights and therapeutic advances in mutation-driven melanoma, highlighting the promise of biomarker-guided combination strategies and signaling crosstalk disruption as the next frontier in precision oncology.

P=N/A, N=33, Recruiting, Princess Alexandra Hospital | Not yet recruiting --> Recruiting

P=N/A, N=150, Recruiting, Abramson Cancer Center at Penn Medicine | Not yet recruiting --> Recruiting

P2, N=42, Active, not recruiting, Massachusetts General Hospital | Recruiting --> Active, not recruiting

P=N/A, N=0, Withdrawn, Duke University | N=500 --> 0 | Not yet recruiting --> Withdrawn

P1, N=194, Recruiting, Hefei TG ImmunoPharma Co., Ltd.