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BIOMARKER:

SKAP2-BRAF fusion

i
Other names: BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1, SKAP2, Src Kinase Associated Phosphoprotein 2, SKAP-HOM, SKAP55R, RA70, SAPS, Src-Associated Adapter Protein With PH And SH3 Domains, Src
Entrez ID:
over2years
SKAP2-BRAF fusion and response to an MEK inhibitor in a patient with metastatic melanoma resistant to immunotherapy. (PubMed, BMJ Case Rep)
SKAP2-BRAF fusions have a dimerisation domain that paradoxically activates the mitogen-activated protein kinase pathway, resulting in hyperproliferation if first-generation or second-generation BRAF inhibitors are used. Our knowledge is limited regarding the complex effects of targeted therapy in rare BRAF fusion proteins.
Clinical • Journal • IO biomarker
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BRAF (B-raf proto-oncogene) • SKAP2 (Src Kinase Associated Phosphoprotein 2)
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BRAF fusion • SKAP2-BRAF fusion