^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    SKAP2-BRAF fusion

    i
    Other names: BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1, SKAP2, Src Kinase Associated Phosphoprotein 2, SKAP-HOM, SKAP55R, RA70, SAPS, Src-Associated Adapter Protein With PH And SH3 Domains, Src
    Entrez ID:
    673; 8935
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over3years
    SKAP2-BRAF fusion and response to an MEK inhibitor in a patient with metastatic melanoma resistant to immunotherapy. (PubMed, BMJ Case Rep)
    SKAP2-BRAF fusions have a dimerisation domain that paradoxically activates the mitogen-activated protein kinase pathway, resulting in hyperproliferation if first-generation or second-generation BRAF inhibitors are used. Our knowledge is limited regarding the complex effects of targeted therapy in rare BRAF fusion proteins.
    Clinical • Journal • IO biomarker
    |
    BRAF (B-raf proto-oncogene) • SKAP2 (Src Kinase Associated Phosphoprotein 2)
    |
    BRAF fusion • SKAP2-BRAF fusion