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    GENE:

    SKAP1 (Src Kinase Associated Phosphoprotein 1)

    i
    Other names: SKAP1, Src Kinase Associated Phosphoprotein 1, SKAP55, SCAP1, Src Kinase-Associated Phosphoprotein Of 55 KDa, Src Kinase-Associated Phosphoprotein 1, Src Family-Associated Phosphoprotein 1, SKAP-55, Pp55, Epididymis Secretory Sperm Binding Protein Li 81p, Src Family Associated Phosphoprotein 1, HEL-S-81p
    3ms
    A Tertiary Lymphoid Structure-Related Gene Signature Predicts Prognosis and Treatment Response in Hepatocellular Carcinoma. (PubMed, World J Oncol)
    We validated this TLS score across multiple independent HCC cohorts, including patients receiving transarterial chemoembolization (TACE), programmed cell death protein-1 (PD-1)/ligand 1 (PD-L1) inhibitors, or lenvatinib...Our findings suggest a potential TLS-based biomarker for HCC prognosis and therapeutic response. This work offers preliminary insights into tumor immune microenvironment (TIME) heterogeneity, which may be modulated by the Treg/Tex balance, and proposes a possible tool for improving patient stratification.
    Journal • Gene Signature • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CCL20 (C-C Motif Chemokine Ligand 20) • CD200 (CD200 Molecule) • PLAC8 (Placenta Associated 8) • SKAP1 (Src Kinase Associated Phosphoprotein 1) • DNASE1L3 (Deoxyribonuclease 1 Like 3)
    |
    Lenvima (lenvatinib)
    5ms
    Integrative Analysis of TLS-Associated Gene Signatures, Immune Infiltration and Drug Sensitivity in Pancreatic Cancer. (PubMed, IET Syst Biol)
    Notably, the TLS_H group demonstrated enhanced sensitivity to chemotherapeutics including AZD8055, axitinib, vorinostat, nilotinib, camptothecin and paclitaxel. Real-time fluorescent quantitative PCR (RT-qPCR) validation in Mia PaCa2 and Jurkat cells indicated that LAT, RBP5 and SKAP1 may play important roles in modulating sensitivity to these chemotherapeutics. These findings establish TLS as a potential biomarker for PAAD, enabling personalised chemotherapy selection by integrating immune contexture and genomic drivers to improve clinical outcomes.
    Journal • Tumor mutational burden • Gene Signature
    |
    TMB (Tumor Mutational Burden) • CD79B (CD79b Molecule) • SKAP1 (Src Kinase Associated Phosphoprotein 1) • CCR6 (C-C Motif Chemokine Receptor 6) • CD1D (CD1d Molecule) • PTGDS (Prostaglandin D2 Synthase)
    |
    paclitaxel • nilotinib • axitinib • Zolinza (vorinostat) • AZD8055
    7ms
    Single-cell RNA sequencing analysis revealed the immunosuppressive remodeling of tumor-associated macrophages mediated by the MIF-CD74 axis in gastric cancer. (PubMed, Sci Rep)
    Crucially, Milatuzumab, a CD74-targeting antibody, reversed MIF-induced TAM immunosuppression in vitro. Our research provides a comprehensive map of GC-TAM heterogeneity; reveals that the MIF-CD74 axis is a key driver of TAM-mediated immune suppression; and proposes that CD74 blockade is a new therapeutic strategy for GC.
    Journal • IO biomarker
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    CD74 (CD74 Molecule) • IDO1 (Indoleamine 2,3-dioxygenase 1) • APOE (Apolipoprotein E) • POLG2 (DNA Polymerase Gamma 2, Accessory Subunit) • SKAP1 (Src Kinase Associated Phosphoprotein 1)
    |
    milatuzumab (IMMU-115)
    8ms
    The effect of circulating proteins and their role in mediating adiposity's effect on endometrial cancer risk: Mendelian randomisation and colocalization analyses. (PubMed, Cancer Epidemiol Biomarkers Prev)
    Prioritised proteins may support non-invasive methods to differentiate endometrial cancer subtypes.
    Journal
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    PTEN (Phosphatase and tensin homolog) • IFI16 (Interferon Gamma Inducible Protein 16) • SKAP1 (Src Kinase Associated Phosphoprotein 1) • MAPK9 (Mitogen-Activated Protein Kinase 9)
    12ms
    Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors. (PubMed, Biochem Biophys Rep)
    We found that SKAP1 levels are positively associated with tumor progression in pNET patients. Overall, our research indicates that the SKAP1-mediated pathway is crucial in pNET development and metastasis.
    Journal
    |
    SKAP1 (Src Kinase Associated Phosphoprotein 1)
    over1year
    SKAP1 Expression in Cancer Cells Enhances Colon Tumor Growth and Impairs Cytotoxic Immunity by Promoting Neutrophil Extracellular Trap Formation via the NFATc1/CXCL8 Axis. (PubMed, Adv Sci (Weinh))
    Furthermore, inhibiting SKAP1-induced NET significantly enhanced the antitumor efficiency of adoptive natural killer cell therapy in colon tumor models. In conclusion, SKAP1 significantly promotes colon cancer growth via the cancer cell/neutrophil NFATc1/CXCL8/NET axis, suggesting that SKAP1 is a potential target for colon cancer therapy.
    Journal
    |
    CXCL8 (Chemokine (C-X-C motif) ligand 8) • SKAP2 (Src Kinase Associated Phosphoprotein 2) • NFATC1 (Nuclear Factor Of Activated T Cells 1) • SKAP1 (Src Kinase Associated Phosphoprotein 1)
    over1year
    Identification and Validation of a Novel Tertiary Lymphoid Structures-Related Prognostic Gene Signature in Hepatocellular Carcinoma. (PubMed, World J Oncol)
    In addition, two subtypes of the TLS score could accurately predict the effectiveness of sorafenib, transcatheter arterial chemoembolization (TACE), and immunotherapy in HCC patients. In this research, we conducted and validated a prognostic model associated with TLS that may be helpful for predicting clinical outcomes and treatment responsiveness for HCC patients.
    Journal • Gene Signature • IO biomarker
    |
    PLAC8 (Placenta Associated 8) • SKAP1 (Src Kinase Associated Phosphoprotein 1) • DNASE1L3 (Deoxyribonuclease 1 Like 3)
    |
    sorafenib
    almost2years
    Integrating Tertiary Lymphoid Structure-Associated Genes into Computational Models to Evaluate Prognostication and Immune Infiltration in Pancreatic Cancer. (PubMed, J Leukoc Biol)
    Therefore, we established a risk model that has significant implications for the prognostic assessment of PADC patients with remarkable differences in immune infiltration and chemo-sensitivity between the low-risk and high-risk groups. And this paradigm established by TLS-related cell marker genes provides a prognostic prediction and a panel of novel therapeutic targets for exploring potential immunotherapy.
    Journal • IO biomarker
    |
    CD79B (CD79b Molecule) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • CCL19 (C-C Motif Chemokine Ligand 19) • CXCL11 (C-X-C Motif Chemokine Ligand 11) • CCL2 (Chemokine (C-C motif) ligand 2) • CCL8 (C-C Motif Chemokine Ligand 8) • CCL21 (C-C Motif Chemokine Ligand 21) • CCL3 (C-C Motif Chemokine Ligand 3) • SKAP1 (Src Kinase Associated Phosphoprotein 1) • CCL18 (C-C Motif Chemokine Ligand 18) • CCR6 (C-C Motif Chemokine Receptor 6) • PTGDS (Prostaglandin D2 Synthase)
    2years
    The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma. (PubMed, Heliyon)
    The TLS score we established effectively predicted immunotherapy response and patients' survival. Its future application and combination await more research.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • SKAP1 (Src Kinase Associated Phosphoprotein 1) • PTGDS (Prostaglandin D2 Synthase)
    |
    PD-L1 expression
    over2years
    Generalized machine learning based on multi-omics data to profile the effect of ferroptosis pathway on prognosis and immunotherapy response in patients with bladder cancer. (PubMed, Environ Toxicol)
    We identified a set of six genes, JUN, SYT1, MAP3K8, GALNT14, TCIRG1, and SKAP1, that exhibited significant potential in stratification of BLCA patients with varying prognosis. In addition, we uncovered the direct regulatory effect of SKAP1 on BLCA cell proliferation and apoptosis, shedding some light on the role of FRGs in pathogenesis of BLCA.
    Journal • IO biomarker • Machine learning
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    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8) • SKAP1 (Src Kinase Associated Phosphoprotein 1) • JUN (Jun proto-oncogene) • TCIRG1 (T Cell Immune Regulator 1, ATPase H+ Transporting V0 Subunit A3)
    |
    gemcitabine • sirolimus • BI2536