Upregulating SIRT3 expression also upregulated other supporting proteins such as PGC-1α, SOD2, GPx, and FOXO3, and these targets have been known to downregulate the reactive oxygen species levels. The study's findings reveal the therapeutic potential of the developed and synthesized compounds and their involvement in such pathological situations; among all the compounds, IM24DCW-16 was discovered to be the most promising candidate for the modulation of the SIRT3 in PD.

We found that resveratrol significantly reversed sleep deprivation-induced learning and memory impairment, elevated interleukin-1β, interleukin-6, and tumor necrosis factor-α levels, and decreased brain-derived neurotrophic factor, tyrosine kinase receptor B, postsynaptic density protein-95, and synaptophysin levels by activating the Sirt1/miR-134 pathway. In conclusion, resveratrol is a promising agent for preventing sleep deprivation-induced cognitive dysfunction by reducing pro-inflammatory cytokines and improving synaptic function via the Sirt1/miR-134 pathway.