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DRUG:

ALTA-002

i
Other names: ALTA-002, TAC-002, SIRPα TRAAC, anti-SIRPα antibody-Toll-like Receptor Agonist Antibody Conjugate, ALTA002, ALTA 002, TAC002, TAC 002
Associations
Trials
Company:
ALX Oncology, Tallac Therap
Drug class:
TLR9 agonist, SIRPA antagonist
Associations
Trials
3years
ALTA-002, a SIRPα-directed TLR9 agonist antibody conjugate activates myeloid cells and promotes anti-tumor immunity (SITC 2021)
Conclusions These results demonstrate the unique properties of systemically administered ALTA-002, which integrates TLR9 activation and blockade of CD47-SIRPα interaction on myeloid cells to engender both innate and adaptive anti-tumor immune responses. These data support the development of ALTA-002 as an anti-cancer therapeutic for a variety of tumor malignancies.
IO biomarker
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SIRPA (Signal Regulatory Protein Alpha)
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ALTA-002