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    DRUG:

    sildenafil

    i
    Other names: UK 92480
    Company:
    Generic mfg.
    Drug class:
    PDE5 inhibitor
    Related drugs:
    4d
    Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer (clinicaltrials.gov)
    P3, N=188, Not yet recruiting, University Hospital, Rouen | Trial completion date: May 2028 --> Feb 2030 | Trial primary completion date: May 2028 --> Feb 2030
    Trial completion date • Trial primary completion date
    |
    sildenafil
    4d
    SHINE1: Sildenafil Plus Hypothermia to Treat Neonatal Encephalopathy (clinicaltrials.gov)
    P2, N=24, Not yet recruiting, Assistance Publique - Hôpitaux de Paris | Trial completion date: Jan 2028 --> May 2029 | Trial primary completion date: Feb 2026 --> Jun 2027
    Trial completion date • Trial primary completion date
    |
    sildenafil
    4d
    MoD: Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension (clinicaltrials.gov)
    P3, N=28, Completed, Johns Hopkins University | Active, not recruiting --> Completed | N=100 --> 28 | Trial completion date: May 2026 --> Dec 2025 | Trial primary completion date: May 2026 --> Dec 2025
    Trial completion • Enrollment change • Trial completion date • Trial primary completion date
    |
    sildenafil
    16d
    Daily Tadalafil 5 mg Combined With On-Demand Sildenafil 100 mg for Treatment of Erectile Dysfunction in PDE-5I Non Responder Patients (clinicaltrials.gov)
    P4, N=500, Recruiting, Mansoura University
    New P4 trial
    |
    sildenafil
    17d
    Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPD (clinicaltrials.gov)
    P2, N=160, Recruiting, University of Alberta | Trial completion date: Dec 2025 --> May 2027 | Trial primary completion date: Dec 2025 --> May 2027
    Trial completion date • Trial primary completion date
    |
    sildenafil
    2ms
    IMPROVE-FALD: IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease (clinicaltrials.gov)
    P1, N=15, Recruiting, Children's Mercy Hospital Kansas City | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
    |
    sildenafil
    2ms
    Anti-Inflammatory and Anti-apoptotic Effects of Phosphodiesterase Inhibitors Against Streptozocin-induced Diabetic Nephropathy. (PubMed, In Vivo)
    The tested PDEIs, pentoxifylline, sildenafil, and milrinone, exhibit significant anti-inflammatory and anti-apoptotic effects, highlighting their potential in slowing the progression of diabetic nephropathy.
    Journal • IO biomarker
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • BAX (BCL2-associated X protein)
    |
    Zanosar (streptozocin) • sildenafil
    2ms
    Sildenafil reduced neuroinflammation and improved white matter injury in a rat model of term neonatal hypoxic-ischemic encephalopathy. (PubMed, Sci Rep)
    Sildenafil significantly reduced neuroinflammation, improved white matter integrity, and supported oligodendrocyte recovery after neonatal HI. These findings highlight the potential of sildenafil as a neurorestorative therapy during the tertiary phase of injury in neonatal HIE.
    Preclinical • Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • GFAP (Glial Fibrillary Acidic Protein) • OLIG2 (Oligodendrocyte Transcription Factor 2)
    |
    sildenafil
    2ms
    Asciminib With or Without Sildenafil for Brain Tumors (clinicaltrials.gov)
    P1, N=12, Not yet recruiting, Washington University School of Medicine | Trial completion date: Jun 2027 --> Aug 2027
    Trial completion date
    |
    CRKL (CRK Like Proto-Oncogene, Adaptor Protein) • ABL2 (ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase)
    |
    Scemblix (asciminib) • sildenafil
    3ms
    Umbilical Cord Mesenchymal Stem Cell Secretome Administration in Severe Erectile Dysfunction Non-responsive to Sildenafil (clinicaltrials.gov)
    P=N/A, N=12, Completed, Indonesia University
    New trial
    |
    sildenafil
    3ms
    SPARC: Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment (clinicaltrials.gov)
    P2/3, N=30, Not yet recruiting, The University of Texas Medical Branch, Galveston | Initiation date: Oct 2025 --> Mar 2026
    Trial initiation date
    |
    sildenafil
    4ms
    SEPVADIS: Sildenafil for Early Pulmonary Vascular Disease in Scleroderma (clinicaltrials.gov)
    P2, N=30, Recruiting, Johns Hopkins University | Trial completion date: Sep 2025 --> Sep 2026 | Trial primary completion date: Sep 2025 --> Sep 2026
    Trial completion date • Trial primary completion date
    |
    sildenafil