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DRUG:

SII OncoBCG (BCG vaccine)

i
Other names: BCG vaccine
Associations
Trials
Company:
Serum Institute of India
Drug class:
Immunostimulant
Related drugs:
Associations
Trials
4ms
Mycobacterium bovis BCG reverses deleterious effects of H. pylori components towards gastric barrier cells in vitro. (PubMed, Biomed Pharmacother)
bovis) Bacillus Calmette-Guerin (BCG) strain used in immunotherapy of bladder cancer (onco-BCG) due to its acid tolerance can be a candidate for prevention or reversion of deleterious effects towards gastric cell barrier initiated by gastric pathogen Helicobacter pylori (Hp) with high resistance to commonly used antibiotics...Similarly, the cell regeneration which was diminished by Hp LPS has been improved in response to mycobacteria. This study reveals that vaccine mycobacteria may reduce gastric barrier damage induced by Hp infection.
Preclinical • Journal • IO biomarker
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TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL1B (Interleukin 1, beta)
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SII OncoBCG (BCG vaccine)
1year
Diminishing of Helicobacter pylori adhesion to Cavia porcellus gastric epithelial cells by BCG vaccine mycobacteria. (PubMed, Sci Rep)
Mycobacterium bovis onco-BCG bacilli used in immunotherapy of bladder cancer are candidates for training of immune cells towards microbial pathogens...Decrease of MUC5AC driven in cell cultures in vitro and in gastric tissue exposed ex vivo to mycobacteria was related to diminished adhesion of H. pylori bacilli. Vaccine mycobacteria by diminishing the amount of MUC5AC in gastric epithelial cells may reduce Hp adhesion.
Journal
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MUC5AC (Mucin 5AC)
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SII OncoBCG (BCG vaccine)
over1year
Mycobacterium bovis BCG increase the selected determinants of monocyte/macrophage activity, which were diminished in response to gastric pathogen Helicobacter pylori. (PubMed, Sci Rep)
Bacillus Calmette-Guerin (BCG) vaccine with Mycobacterium bovis (Mb) is a candidate for modulation the activity of immunocompetent cells, and onco-BCG formulation was successfully used in immunotherapy of bladder cancer...Preliminary results indicate that BCG mycobacteria may also induce the phagocytosis of H. pylori by THP-1 monocytes. Priming or priming and restimulation of monocytes/macrophages with BCG resulted in an increased activity of these cells, which was negatively modulated by Hp.
Journal • IO biomarker
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CD14 (CD14 Molecule) • ITGAM (Integrin, alpha M) • ITGB2 (Integrin Subunit Beta 2)
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SII OncoBCG (BCG vaccine)