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    GENE:

    SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein)

    i
    Other names: SHOC2, SHOC2 Leucine Rich Repeat Scaffold Protein, Leucine-Rich Repeat Protein SHOC-2, Soc-2 (Suppressor Of Clear, C.Elegans) Homolog, Soc-2 Suppressor Of Clear Homolog (C. Elegans), SHOC2, Leucine Rich Repeat Scaffold Protein, SHOC2 Leucine-Rich Repeat Scaffold Protein, Soc-2 Suppressor Of Clear Homolog, Protein Soc-2 Homolog, Protein Sur-8 Homolog, SIAA0862, KIAA0862, SOC2, SUR8
    2ms
    Noonan Syndrome Spectrum Disorders Predispose to Systemic Lupus Erythematosus: Case Report and Critical Review of the Literature. (PubMed, Am J Med Genet A)
    Our case represents the first reported case of SLE in a patient with a SOS1 pathogenic variant. Compared to the general SLE population, SLE in the presence of NSSD develops at a younger age, with a similar prevalence among females and males, suggesting a contribution of the RAS/MAPK pathway in the development of SLE.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11) • SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein)
    almost3years
    LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis. (PubMed, Aging (Albany NY))
    In summary, our study revealed that down-regulation of FALEC could inhibit the proliferation, migration, and invasion of CCA cells in vitro by regulating the miR-20a-5p/SHOC2 axis and participating in 5-FU resistance by mediating the ERK1/2 signaling pathway.
    Journal
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    SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein) • MIR20A (MicroRNA 20a)
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    5-fluorouracil
    4years
    Assessment of the perceived burden associated with Malignant Melanoma with Pictorial Representation of Illness and Self Measure (PRISM) and Melanoma Concerns Questionnaire (MCQ-28). (PubMed, Support Care Cancer)
    In the study population, mostly affected with superficial MM, their perception of the burden associated with MM did not appear either particularly dramatic or disabling. PRISM seems a reliable system for capturing and quantifying the domains correlated with the emotive dimension of MM, especially MM-related concerns and willingness to face life.
    Journal
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    SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein)