SHMT1 (Serine Hydroxymethyltransferase 1)

This study presents a validated prognostic risk score model comprising AAMRGs in LSCC. Furthermore, our findings highlight the downregulation of SHMT1 in LSCC and its significant association with patient prognosis and tumor stage.

Considering expression frequency, specificity, and functional relevance, FTCD, GPD1, SOD2, and EIF4B Ser422 phosphorylation are further identified and validated as subtype prognostic biomarkers. This study provides critical insights into the molecular mechanisms underlying CRLM and offers resources for high-risk metastatic CRC.

Our results revealed significant associations between amino acid metabolism gene polymorphisms and PTC risk, suggesting potential biomarkers for PTC susceptibility.

Furthermore, we obtained an X-ray structure of TthSHMT in complex with the substrate THF, which binds identically as 5MTHF at the peripheral binding site. The unique structural and functional information provided by neutron crystallography, in combination with X-ray structures, can be employed in the rational design of SHMT inhibitors.

While current evidence is predominantly preclinical, sertraline's multi-targeted action and established safety profile support its candidacy for repurposing. Further translational research and biomarker-driven clinical trials are warranted to validate its therapeutic niche and optimize its integration into oncology.

Folate transporter-null HeLa cells were engineered to express RFC under the control of a tetracycline-inducible promoter...The results document the therapeutic promise of classical multitargeted pyrrolo[3,2-d]pyrimidine antifolates typified by AGF347. These novel compounds offer an exciting new platform for one-carbon-targeted drug development for cancer.

In this review, we aimed to highlight the therapeutic potential of targeting SHMT and offer insights into the development of innovative treatment strategies in oncology and metabolic medicine. These insights support the hypothesis that targeting SHMT, particularly isoform-specific inhibition, may provide novel therapeutic avenues in both oncology and metabolic medicine.

Therefore, the research on abnormal expression of SHMT in tumor cells has profound significance for the diagnosis and treatment of cancer. This article reviews the structure, biological process, markers, and related drug treatment of SHMT protein, providing new ideas for the diagnosis and treatment of tumors.

With the use of ketamine, Glutamate (Glu) system has gradually become the focus of antidepressant effects...For patients with acute MDD, after effective antidepressant treatment, the greater the improvement in cognitive impairment, the smaller the change in Gly. The improvement of depressive and anxiety symptoms, the reduction of feelings of despair, and the alleviation of somatic anxiety symptoms are associated with inflammatory cytokines.

At the same time, it can inhibit the expression of epithelial-mesenchymal transition (EMT)-related proteins vimentin, fibronectin, and N-cadherin, ultimately inhibiting the proliferation, migration, and invasion of BC cells, and increasing the apoptosis level of BC cells to improve the development of BC. Our study confirmed that the upregulation of miR-944 may become a new target for the treatment of BC.

Our study provides the most comprehensive ABC regulatory maps of the liver to date. This resource offers a valuable reference for identifying regulatory variants and prioritizing susceptibility genes of liver diseases, such as NAFLD.