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    GENE:

    SH3PXD2A (SH3 And PX Domains 2A)

    i
    Other names: SH3PXD2A, SH3 And PX Domains 2A, FISH, KIAA0418, SH3MD1, Tyrosine Kinase Substrate With Five SH3 Domains, SH3 And PX Domain-Containing Protein 2A, Five SH3 Domain-Containing Protein, SH3 Multiple Domains 1, Adapter Protein TKS5, TKS5, SH3 Multiple Domains Protein 1, Adaptor Protein TKS5, Five SH3 Domains
    Associations

    News

    Trials
    3d
    Application of interpretable machine learning to analyze DNA methylation sites in the progression from oral Leukoplakia to oral squamous cell carcinoma. (PubMed, Integr Biol (Camb))
    These multi-layered analyses provide novel insights into epigenetic mechanisms underlying OL to OSCC progression and highlight candidate biomarkers with strong translational potential. By combining IML based methylation modeling with external and cross-omics validation, this study advances the development of reliable, interpretable biomarkers for precision oral cancer diagnostics and management.
    Journal
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    TNFRSF9 (TNF Receptor Superfamily Member 9) • FOXP1 (Forkhead Box P1) • SH3PXD2A (SH3 And PX Domains 2A) • TNFRSF19 (TNF Receptor Superfamily Member 19)
    5ms
    Identification of novel gene fusions in high-grade serous ovarian carcinoma: implications for tumorigenesis and targeted therapy. (PubMed, Cancer Genet)
    This study identified candidate driver fusion genes and suggested new therapeutic targets for HGSOCs.
    Journal
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    ER (Estrogen receptor) • TP53 (Tumor protein P53) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • AXL (AXL Receptor Tyrosine Kinase) • HDAC1 (Histone Deacetylase 1) • CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta) • LATS1 (Large Tumor Suppressor Kinase 1) • PSMD1 (Proteasome 26S Subunit Non-ATPase 1) • BMPR1A (Bone Morphogenetic Protein Receptor Type 1A) • CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1) • HNRNPUL1 (Heterogeneous Nuclear Ribonucleoprotein U Like 1) • SH3PXD2A (SH3 And PX Domains 2A) • YY1 (YY1 Transcription Factor) • ZNF143 (Zinc Finger Protein 143)
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    TP53 mutation
    5ms
    Genetic and clinical characteristics of cranial nerve schwannoma harboring SH3PXD2A-HTRA1 fusion gene. (PubMed, Acta Neuropathol)
    It may contribute to tumorigenesis through an alternative pathway independent of NF2. Our findings provide a basis for future clinical investigations.
    Retrospective data • Journal
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    HTRA1 (HtrA Serine Peptidase 1) • SH3PXD2A (SH3 And PX Domains 2A)
    6ms
    Widening the Spectrum of Fusion Events in Schwannoma: Identification of a Novel TANC1::HTRA1 Fusion. (PubMed, Genes Chromosomes Cancer)
    We describe a schwannoma arising in the periportal region in which a novel TANC1::HTRA1 fusion was identified. The identification of this variant expands the range of fusion drivers in schwannoma and offers insight into the pathogenic mechanism of HTRA1 fusions and their utility in molecular diagnosis.
    Journal
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    NOTCH1 (Notch 1) • HTRA1 (HtrA Serine Peptidase 1) • SH3PXD2A (SH3 And PX Domains 2A)
    7ms
    Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas. (PubMed, Discov Oncol)
    This study provides evidence and explores the biological significance of BET1L, COL17A1, CFAP43, SH3PXD2A, TTC28, ZNRF3, SLK, AKR1C3, NRXN3, and RSPO3 as potential therapeutic targets for meningiomas, providing new insights into the development of targeted therapy for meningiomas.
    Journal
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    RSPO3 (R-Spondin 3) • COL17A1 (Collagen Type XVII Alpha 1 Chain) • SH3PXD2A (SH3 And PX Domains 2A) • ZNRF3 (Zinc And Ring Finger 3)
    7ms
    Tks5 interactome reveals endoplasmic-reticulum-associated translation machinery in invadosomes. (PubMed, FEBS J)
    We identified elements of the translation machinery, in particular the eukaryotic translation initiation factor 4B (EIF4B) protein, but also endoplasmic reticulum (ER) proteins as part of the invadosome structure. Providing new data on invadosome molecular composition through the Tks5 interactome, we identified that ER-associated translation machinery is recruited to invadosomes and involved in their formation, persistence, and function in all types of invadosomes.
    Journal
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    SH3PXD2A (SH3 And PX Domains 2A)
    10ms
    Genetic Analysis of Intracranial Schwannomas: Differential NF2 Alteration Frequencies in Nonvestibular Schwannomas Versus Vestibular Schwannomas. (PubMed, Neurosurgery)
    Our results suggested the potential involvement of factors other than NF2 inactivation in tumorigenesis, especially in non-VS. However, further comprehensive molecular analyses are warranted.
    Journal
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    NF2 (Neurofibromin 2) • SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • HTRA1 (HtrA Serine Peptidase 1) • LZTR1 (Leucine Zipper Like Transcription Regulator 1) • SH3PXD2A (SH3 And PX Domains 2A)
    10ms
    In-frame insertions of SOX10 are highly enriched and characterize a distinct transcriptomic profile in gastrointestinal schwannomas. (PubMed, J Pathol)
    This study highlights the genetic heterogeneity of schwannomas and suggests that SOX10 insertions play a pivotal role in the tumorigenesis of gastrointestinal schwannomas, distinctly separating them from non-gastrointestinal counterparts and contributing to their unique molecular profile.
    Journal
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    NF2 (Neurofibromin 2) • SOX10 (SRY-Box 10) • HTRA1 (HtrA Serine Peptidase 1) • SH3PXD2A (SH3 And PX Domains 2A)
    1year
    Current molecular understanding of central nervous system schwannomas. (PubMed, Acta Neuropathol Commun)
    A deeper exploration of these molecular findings could clarify the mechanisms of schwannoma tumorigenesis and progression, ultimately guiding the development of new therapeutic targets. This review offers a comprehensive overview of the current molecular understanding of CNS schwannomas, emphasizing the insights gained from previous research, while addressing existing controversies and outlining future research and treatment perspectives.
    Review • Journal
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    NF2 (Neurofibromin 2) • SOX10 (SRY-Box 10) • HTRA1 (HtrA Serine Peptidase 1) • SH3PXD2A (SH3 And PX Domains 2A)
    1year
    Clinical and Pathological Features of a Schwannoma Harboring a SH3PXD2A::HTRA1 Gene Fusion in a Pre-pubescent Patient. (PubMed, Pediatr Dev Pathol)
    This pre-pubescent girl (Tanner Stage 2) is currently the youngest reported case of fusion-positive schwannoma. In addition, she has a significant prior history of a malignant neoplasm, and the lesion arose in an appendicular location.
    Journal
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    MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • HTRA1 (HtrA Serine Peptidase 1) • SH3PXD2A (SH3 And PX Domains 2A)
    over1year
    Tristetraprolin affects invasion-associated genes expression and cell motility in triple-negative breast cancer model. (PubMed, Cytoskeleton (Hoboken))
    High TTP expression is considered as a positive prognostic marker in multiple cancers, including BC. Given that doxorubicin is a commonly used drug for treating triple-negative BC, using TTP as a prognostic marker in this cohort of patients might be limited since it might be challenging to understand if high TTP expression occurred due to the favorable physiological state of the patient or as a consequence of treatment.
    Preclinical • Journal
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    CTTN (Cortactin) • SH3PXD2A (SH3 And PX Domains 2A) • SH3PXD2B (SH3 And PX Domains 2B)
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    doxorubicin hydrochloride
    over1year
    LncRNA SH3PXD2A-AS1 facilitates cisplatin resistance in non-small cell lung cancer by regulating FOXM1 succinylation. (PubMed, BMC Cancer)
    SH3PXD2A-AS1 promoted DDP resistance in NSCLC cells by regulating FOXM1 SUCC via SIRT7, offering a promising therapeutic approach for NSCLC.
    Journal
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    FOXM1 (Forkhead Box M1) • SH3PXD2A (SH3 And PX Domains 2A) • SH3PXD2A-AS1 (SH3PXD2A Antisense RNA 1) • SIRT7 (Sirtuin 7)
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    cisplatin