SH3GL2 (SH3 Domain Containing GRB2 Like 2)

Based on our findings, it is possible to conclude that endophilin A isoforms-long recognised for orchestrating endocytosis and metastatic behaviour-may represent a critical molecular fulcrum in breast cancer progression. In particular, elevated expression of endophilin A2 (SH3GL1) and SH3GL2 strongly correlates with poor prognosis and node-positive breast cancer, highlighting their potential as promising biomarkers for breast cancer assessment.

It further addresses how these functions contribute to physiological processes and the development of pathologies, with a particular focus on cancer pathophysiology. Together, it emphasizes non-redundant roles of EndoA proteins in various cellular processes and highlights the complex relationship between membrane trafficking and diseases.

Thus, Synj1, EndoA1, Dnm1, and AAK1 mediate SV recycling and are thus required for sustained synaptic transmission in nociceptive spinal circuits. Disruption of SV recycling effectively reduces nociceptive transmission, providing a novel strategy for pain relief.

Finally, we downregulated MMP17 and upregulated SH3GL2 gene expression, then the CCK8 showed that the proliferation of both lung cancer cells was inhibited. SH3GL2 and MMP17 are expected to be potential biomarkers for Lung adenocarcinoma.

Malignant PCPGs tend to be aggressive in imaging and pathology. The high expression of CNTN4 and SH3GL2 in PCPGs may indicate a poor prognosis.