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    GENE:

    SH3D19 (SH3 Domain Containing 19)

    i
    Other names: SH3D19, SH3 Domain Containing 19, SH3 Domain-Containing Protein 19, ADAM-Binding Protein Eve-1, EEN-Binding Protein, EBP, SH3 Domain Protein D19, EEN Binding Protein, SH3P19, Eve-1, EVE1, Kryn
    3ms
    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer. (PubMed, Nat Cell Biol)
    Genetic deletion of RASH3D19 in mutant KRAS-expressing cancer cells exhibits growth retardation in vitro, in vivo and sensitized pancreatic ductal adenocarcinoma and colorectal cancer cells, organoids and xenografts to mutant KRAS inhibitors, suppressing feedback reactivation of RAS pathways. Therapeutic targeting of RASH3D19 is expected to lead to tumour debulking and alleviating resistance to KRAS inhibitors in mutant KRAS-expressing cancers.
    Journal
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    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • ETS1 (ETS Proto-Oncogene 1) • SH3D19 (SH3 Domain Containing 19) • GAB1 (GRB2 Associated Binding Protein 1) • MIR222 (MicroRNA 222)
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    KRAS mutation
    over1year
    Radiation-sensitive circRNA hsa_circ_0096498 inhibits radiation-induced liver fibrosis by suppressing EIF4A3 nuclear translocation to decrease CDC42 expression in hepatic stellate cells. (PubMed, J Transl Med)
    Collectively, our findings elucidate the involvement of the circ96498/EIF4A3/CDC42 axis in inhibiting irradiated HSC activation, which offers a novel approach for RILF prevention and treatment.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDC42 (Cell Division Cycle 42) • IL1B (Interleukin 1, beta) • SH3D19 (SH3 Domain Containing 19) • EIF4A3 (Eukaryotic Translation Initiation Factor 4A3)
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    IL6 expression