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    BIOMARKER:

    SH3BGRL overexpression

    i
    Other names: SH3BGRL, SH3 Domain Binding Glutamate Rich Protein Like, SH3 Domain Binding Glutamic Acid-Rich Protein Like, SH3 Domain-Binding Glutamic Acid-Rich-Like Protein, MGC117402, SH3-Binding Domain Glutamic Acid-Rich Protein Like, Epididymis Secretory Protein Li 115, HEL-S-115, SH3BGR
    Entrez ID:
    6451
    almost3years
    SH3BGRL Suppresses Liver Tumor Progression through Enhanced ATG5-Dependent Autophagy. (PubMed, J Oncol)
    The relevance of SH3BGRL downregulation in liver cancers and their progression is validated based on the large-scale tumor data. Taken together, our results clarify the suppressive role of SH3BGRL in tumorigenesis of liver cancer, which would be of help to the diagnosis of liver cancer, while either promoting the autophagy of liver cancer cells or inhibiting the downstream signaling induced from SH3BGRL downregulation would be a promising therapy.
    Journal
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    ATG5 (Autophagy Related 5) • SH3BGRL (SH3 Domain Binding Glutamate Rich Protein Like)
    |
    ATG5 overexpression • SH3BGRL overexpression • ATG5 expression