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    GENE:

    SGPP1 (Sphingosine-1-Phosphate Phosphatase 1)

    i
    Other names: SGPP1, Sphingosine-1-Phosphate Phosphatase 1, Sphingosine-1-Phosphate Phosphohydrolase 1, Sphingosine-1-Phosphatase 1, HSPPase1, SPPase1, SPP-1, HSPP1, Spp1, SPP1
    Associations

    News

    Trials
    over2years
    Tribulus terrestris L. induces cell apoptosis of breast cancer by regulating sphingolipid metabolism signaling pathways. (PubMed, Phytomedicine)
    In conclusion, TT demonstrates therapeutic effects in a mouse model of breast cancer, and its mechanism of action involves the regulations of sphingolipid metabolism signaling pathways. This study lends credence to the pharmacological potential of TT extract as a breast cancer therapy.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • KDR (Kinase insert domain receptor) • BAX (BCL2-associated X protein) • SPHK1 (Sphingosine Kinase 1) • SGPP1 (Sphingosine-1-Phosphate Phosphatase 1)