^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    SFRP1 (Secreted frizzled related protein 1)

    i
    Other names: SFRP1, Secreted Frizzled Related Protein 1, FRP-1, SARP2, FRP, Secreted Apoptosis-Related Protein 2, Secreted Frizzled-Related Protein 1, SARP-2, SFRP-1, FRP1, Frizzled-Related Protein, SFRP1, FrzA
    11d
    Identification of Prognostic Genes and Establishment of a Risk Score Model Related to Pancreatic Adenocarcinoma and Brown Adipose Tissue Based on Transcriptomics and Experimental Validation. (PubMed, Genes (Basel))
    Notable differences between the high- and low-risk groups were found in immune pathways, cell infiltration, tumor mutational burden, and drug sensitivity (e.g., axitinib). SERPINB5, SFRP1, and TFRC were highly expressed in PAAD samples, providing new insights into potential therapeutic strategies in PAAD treatment.
    Journal • Tumor mutational burden
    |
    TMB (Tumor Mutational Burden) • SFRP1 (Secreted frizzled related protein 1)
    |
    axitinib
    11d
    Alterations in the transcriptional profile of genes in tumors as a prerequisite for personalization of treatment in breast cancer patients (PubMed, Arkh Patol)
    Comparative mRNA expression analysis confirms that a short preoperative course of aromatase inhibitors induces a more potent and uniform molecular response, characterized by profound suppression of proliferation and complete inhibition of estrogen-dependent signaling. Tamoxifen therapy is also effective but results in less pronounced suppression of key targets and, crucially, may be accompanied by early activation of the MYC oncogene, a potential marker for resistance development.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • ER (Estrogen receptor) • PGR (Progesterone receptor) • PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CCND1 (Cyclin D1) • CCNE1 (Cyclin E1) • FGFR4 (Fibroblast growth factor receptor 4) • BIRC5 (Baculoviral IAP repeat containing 5) • TYMS (Thymidylate Synthetase) • AURKA (Aurora kinase A) • FOXA1 (Forkhead Box A1) • PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • BAG1 (BAG Cochaperone 1) • EMSY (EMSY Transcriptional Repressor BRCA2 Interacting) • GATA3 (GATA binding protein 3) • KRT5 (Keratin 5) • MMP11 (Matrix Metallopeptidase 11) • MYBL2 (MYB Proto-Oncogene Like 2) • SFRP1 (Secreted frizzled related protein 1) • TMEM45B (Transmembrane Protein 45B) • ANLN (Anillin Actin Binding Protein) • CCNB1 (Cyclin B1) • SCGB2A2 (Secretoglobin Family 2A Member 2) • ZNF703 (Zinc Finger Protein 703)
    |
    HER-2 negative • HER-2 expression
    |
    tamoxifen • letrozole • anastrozole
    3ms
    Mechanisms of synergistic regulation of the tumor microenvironment by fibroblasts and keratinocytes in esophageal squamous cell carcinoma. (PubMed, Discov Oncol)
    This study elucidates the synergistic regulatory mechanisms between fibroblasts and keratinocytes within the tumor microenvironment of ESCC. These findings offer a novel theoretical foundation for molecular classification, prognosis prediction, and precision treatment of ESCC.
    Journal
    |
    SFRP1 (Secreted frizzled related protein 1) • SLIT2 (Slit Guidance Ligand 2)
    3ms
    CTTN overexpression in HNSCC inhibits Anoikis-apoptosis. (PubMed, Sci Rep)
    Furthermore, we found that inhibiting the apoptosis-related gene CTTN suppresses the anti-apoptotic capacity of HNSCC. Results from HNSCC-PDOs suggest that CTTN may represent a key target for HNSCC invasion and treatment.
    Journal
    |
    TTN (Titin) • SPP1 (Secreted Phosphoprotein 1) • PLK1 (Polo Like Kinase 1) • MAPK1 (Mitogen-activated protein kinase 1) • SLCO1B3 (Solute carrier organic anion transporter family member 1B3) • CEACAM1 (CEA Cell Adhesion Molecule 1) • SFRP1 (Secreted frizzled related protein 1) • SPINK1 (Serine peptidase inhibitor, kazal type 1) • CTTN (Cortactin) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MAPK11 (Mitogen-Activated Protein Kinase 11) • PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2 ) • PLAU (Plasminogen Activator) • PTK2 (Protein Tyrosine Kinase 2) • SPHK1 (Sphingosine Kinase 1)
    4ms
    Downregulation of SFRP1 in Enzalutamide-Resistance Prostate Cancer is Associated with Angiogenesis and Regulatory T Cell Infiltration. (PubMed, Arch Esp Urol)
    In conclusion, the downregulation of SFRP1 in enzalutamide-resistance PC is associated with angiogenesis and cellular infiltration. This study identified SFRP1 as a diagnostic biomarker for patients with PC who have developed acquired enzalutamide resistance. These findings provide an important theoretical foundation for the development of novel and complementary therapeutic approaches for PC management.
    Journal
    |
    SFRP1 (Secreted frizzled related protein 1)
    |
    Xtandi (enzalutamide)
    4ms
    Secreted Frizzled-Related Protein 1a regulates hematopoietic development in a dose-dependent manner. (PubMed, Dev Biol)
    High-dose sfrp1a overexpression mimics the loss-of-function phenotype, with elevated canonical Wnt signaling, increased HSPCs, and decreased lymphoid and myeloid differentiation. These results emphasize the importance of dose-dependent Sfrp regulation, paralleling observations in hematopoietic cancers where SFRP1 variants can either promote or inhibit tumor development.
    Journal
    |
    SFRP1 (Secreted frizzled related protein 1)
    6ms
    Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression. (PubMed, Nat Commun)
    Surprisingly, it does so through reprogramming the tumor's stem-like methylome into an astrocyte-like one. Our findings offer a framework for patient stratification with prognostic value, biomarker identification, and therapeutic avenues to halt GBM progression.
    Clinical • Journal
    |
    SFRP1 (Secreted frizzled related protein 1)
    6ms
    Biomarker discovery for early breast cancer diagnosis using machine learning on transcriptomic data for biosensor development. (PubMed, Comput Biol Med)
    The influence of MLA on F1 Macro and Accuracy was not statistically significant. Altogether, the genetic biomarkers identified in this study hold potential for use in biosensors aimed at breast cancer diagnosis and treatment.
    Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • FOXA1 (Forkhead Box A1) • FOXC1 (Forkhead Box C1) • MFSD2A (MFSD2 Lysolipid Transporter A) • MLPH (Melanophilin) • SFRP1 (Secreted frizzled related protein 1) • CACNA1H (Calcium Voltage-Gated Channel Subunit Alpha1 H)
    7ms
    Integrated network toxicology and bioinformatics reveal PFAS-driven prognostic biomarkers and molecular mechanisms in breast cancer: insights from transcriptome analysis and molecular docking. (PubMed, Discov Oncol)
    PFAS exposure is linked to altered gene expression, immune cell infiltration, and potential disruptions in key genes, contributing to breast cancer development and progression. These findings provide insights into potential therapeutic targets and underline the importance of addressing environmental factors in breast cancer management.
    Journal • BRCA Biomarker
    |
    IFNG (Interferon, gamma) • DNMT3B (DNA Methyltransferase 3 Beta) • SFRP1 (Secreted frizzled related protein 1)
    8ms
    Epigenetics and Expression of the Wnt Signaling Pathway in Ulcerative Colitis. (PubMed, Turk J Gastroenterol)
    In ulcerative colitis, inflammation is thought to be associated with both increased APC2 methylation and decreased expression findings due to decreased SFRP4 methylation in non-inflamed areas. However, more research is needed to establish a link with ulcerative colitis-related neoplasia.
    Journal
    |
    SFRP1 (Secreted frizzled related protein 1) • SFRP4 (Secreted frizzled-related protein 4)
    8ms
    Promoter hypermethylation of SFRP1 is an allele fraction-dependent prognostic biomarker in metastatic pancreatic ductal adenocarcinoma. (PubMed, Front Oncol)
    phSFRP1low had a worse prognosis than umSFRP1 at only 12 months, indicating dynamic changes. This could help personalize the treatment of PDAC.
    Journal
    |
    EPHA3 (EPH receptor A3) • SFRP1 (Secreted frizzled related protein 1)
    8ms
    SFRP1 and SFRP2 jointly regulate normal and malignant hematopoietic progenitors by influencing mesenchymal cells in the hematopoietic niche. (PubMed, Biochem Biophys Res Commun)
    Additionally, addition of blocking antibodies to OP-9 MSC monoculture attenuated cell growth. Overall, our findings suggest that SFRP1 and SFRP2 maintain normal and malignant HSPC functions in the hematopoietic niche by modulating the Wnt and bone morphogenetic protein pathways in MSCs.
    Journal
    |
    SFRP1 (Secreted frizzled related protein 1)