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    GENE:

    SFMBT2 (Scm Like With Four Mbt Domains 2)

    i
    Other names: SFMBT2, Scm Like With Four Mbt Domains 2, KIAA1617, Scm-Related Gene Containing Four Mbt Domains 2, Scm-Like With Four MBT Domains Protein 2, Scm-Like With 4 MBT Domains Protein 2
    Associations

    News

    Trials
    15d
    bayesReact: expression-coupled regulatory motif analysis detects microRNA activity across cancers, tissues, and at the single-cell level. (PubMed, Nucleic Acids Res)
    bayesReact enables large-scale hypothesis-generating screens for novel regulatory factors and the discovery of condition-specific activities. It is implemented as a user-friendly R package (https://github.com/JakobSkouPedersenLab/bayesReact).
    Journal
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    MIR122 (MicroRNA 122) • SFMBT2 (Scm Like With Four Mbt Domains 2) • MIR124-3 (MicroRNA 124-3)
    3ms
    Evaluating plasma and tissue biopsy for DNA methylation markers in early colorectal cancer detection: a systematic review. (PubMed, Asian Biomed (Res Rev News))
    QUADAS-2 illustrated a potential high risk of bias in patient selection and flow/timing domains, which underscores the need for more standardized diagnostic workflows and assay protocols. Future research should focus on multi-marker panels, adherence to regulatory thresholds, cost-effectiveness analyses, and clear clinical management pathways to facilitate the widespread implementation of plasma-based CRC screening.
    Journal
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    SEPTIN9 (Septin 9) • SFMBT2 (Scm Like With Four Mbt Domains 2)
    3ms
    CRISPRi Screen Identifies a Novel Growth Suppressor lncRNA, INSTAR , in Human Monocytes. (PubMed, bioRxiv)
    Functional assays confirmed that both genes suppress cell growth, revealing a cis-regulatory mechanism in which INSTAR regulates SFMBT2 expression to control monocyte proliferation. Here, we leverage high-throughput screening to rapidly pinpoint functional lncRNAs providing novel insights into a key regulatory locus consisting of INSTAR and SFMBT2 which could be critical for better understanding dysregulation contributing to acute myeloid leukemia.
    Journal
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    SFMBT2 (Scm Like With Four Mbt Domains 2)
    over1year
    Advances in blood DNA methylation-based assay for colorectal cancer early detection: a systematic updated review. (PubMed, Gastroenterol Hepatol Bed Bench)
    Enhancing sensitivity and specificity of molecular screening methods is crucial for improving CRC detection. Identifying a select few valuable biomarkers is key to reducing costs, despite challenges posed by low ctDNA levels in plasma, particularly in early-stage cancers.
    Review • Journal • Epigenetic controller
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    GFRA1 (GDNF Family Receptor Alpha 1) • SFRP1 (Secreted frizzled related protein 1) • SDC2 (Syndecan 2) • SEPTIN9 (Septin 9) • SFMBT2 (Scm Like With Four Mbt Domains 2) • ZFHX4 (Zinc Finger Homeobox 4)
    almost2years
    Acetylation- and ubiquitination-regulated SFMBT2 acts as a tumor suppressor in clear cell renal cell carcinoma. (PubMed, Biol Direct)
    SFMBT2 exerted an anti-tumor role in clear cell RCC cells, and HDAC3-mediated deacetylation promoted SIAH1-controlled ubiquitination of SFMBT2. SFMBT2 may be considered as a novel clinical diagnostic marker and/or therapeutic target of clear cell RCC, and crosstalk between its post-translational modifications may provide novel insights for agent development.
    Journal
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    HDAC3 (Histone Deacetylase 3) • SFMBT2 (Scm Like With Four Mbt Domains 2)
    almost2years
    Diagnostic and prognostic role of long non-coding RNAs (lncRNAs) in metastatic melanoma patients with BRAF gene mutation receiving BRAF and MEK inhibitors. (PubMed, Heliyon)
    The obtained results require validation on a larger group of patients. If the results are confirmed, the indicated lncRNAs may play an important role as diagnostic and prognostic markers.
    Journal • Metastases
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    SFMBT2 (Scm Like With Four Mbt Domains 2)
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    BRAF mutation • BRAF V600
    2years
    A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma. (PubMed, Sci Rep)
    The risk score showed a strong correlation with the tumor microenvironment, drug sensitivity and many immune checkpoints. In summary, our study sheds a new light on the CIC-related epigenetic modulation mechanism of osteosarcoma and helps search for potential drugs for osteosarcoma treatment.
    Journal • IO biomarker
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    SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • SP140 (SP140 Nuclear Body Protein) • CHD2 (Chromodomain Helicase DNA Binding Protein 2) • SFMBT2 (Scm Like With Four Mbt Domains 2)
    2years
    CircSFMBT2 Plays an Oncogenic Role in Lung Adenocarcinoma Depending on the miR-1305/SALL4 Axis. (PubMed, Biochem Genet)
    MiR-1305 overexpression repressed the malignant phenotypes of LUAD cells, while SALL4 enhancement abated the effects. CircSFMBT2 aggravated the progression of LUAD by the miR-1305/SALL4 axis, which might provide a diagnostic and prognostic marker for LUAD.
    Journal
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    PCNA (Proliferating cell nuclear antigen) • SALL4 (Spalt Like Transcription Factor 4) • SFMBT2 (Scm Like With Four Mbt Domains 2) • TCF4 (Transcription Factor 4)
    2years
    Effects of circ-SFMBT2 on Proliferation, Migration and Invasion of Acute Myeloid Leukemia Cells by Regulating miR-491-5p/HOXA9 Axis (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)
    Silencing of circ-SFMBT2 may inhibit the proliferation, migration and invasion of AML cells by regulating the miR-491-5p/HOXA9 axis.
    Journal
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    HOXA9 (Homeobox A9) • SFMBT2 (Scm Like With Four Mbt Domains 2)
    over2years
    Methylated DNA Markers for Sporadic Colorectal and Endometrial Cancer Are Strongly Associated with Lynch Syndrome Cancers. (PubMed, Cancer Prev Res (Phila))
    Early detection biomarkers for LS cancers could reduce the needs for invasive screening and surgery. Methylated DNA markers previously identified in sporadic endometrial cancer and colorectal cancer discriminate between benign and cancer tissue in LS.
    Journal
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    PPP2R5C (Protein Phosphatase 2 Regulatory Subunit B'Gamma) • SFMBT2 (Scm Like With Four Mbt Domains 2)
    over2years
    circRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells. (PubMed, Cell Death Dis)
    Furthermore, the circRNA-SFMBT2/RNF181 axis differentially regulated K48-linked and K63-linked ubiquitination of ERα to enhance ERα stability, resulting in increased expression of ERα target genes and tumor progression. In summary, circRNA-SFMBT2 is an important regulator of ERα signaling, and antagonizing circRNA-SFMBT2 expression may constitute a potential therapeutic strategy for breast cancer.
    Journal
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    ER (Estrogen receptor) • SFMBT2 (Scm Like With Four Mbt Domains 2)
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    ER positive
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    tamoxifen
    over2years
    Optical Genome Mapping Identifies Novel Recurrent Structural Alterations in Childhood ETV6::RUNX1+ and High Hyperdiploid Acute Lymphoblastic Leukemia. (PubMed, Hemasphere)
    We detected 3 novel fusion genes (SFMBT2::DGKD, PDS5B::STAG2, and TDRD5::LPCAT2), for which the sequence and expression were validated by long-read and whole transcriptome sequencing, respectively. OGM and WES identified double hits of SVs and SNVs (ETV6, BTG1, STAG2, MANBA, TBL1XR1, NSD2) in the same patient demonstrating the power of the combined approach to define the landscape of genomic alterations in BCP-ALL.
    Journal
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • RUNX1 (RUNX Family Transcription Factor 1) • ETV6 (ETS Variant Transcription Factor 6) • IKZF1 (IKAROS Family Zinc Finger 1) • PAX5 (Paired Box 5) • STAG2 (Stromal Antigen 2) • CD4 (CD4 Molecule) • DGKD (Diacylglycerol Kinase Delta) • DRD5 (Dopamine Receptor D5) • GPRC5A (G Protein-Coupled Receptor Class C Group 5 Member A) • IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta) • LPCAT2 (Lysophosphatidylcholine Acyltransferase 2) • NSD2 (Nuclear Receptor Binding SET Domain Protein 2) • SFMBT2 (Scm Like With Four Mbt Domains 2) • TBL1XR1 (TBL1X Receptor 1)
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    IKZF1 deletion