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    BIOMARKER:

    SETD5 overexpression

    i
    Other names: SETD5, SET Domain Containing 5, SETD5A, Histone-Lysine N-Methyltransferase SETD5, SET Domain-Containing Protein 5, FLJ10707, KIAA1757, MRD23
    Entrez ID:
    55209
    almost2years
    Knockdown of SETD5 Inhibits Colorectal Cancer Cell Growth and Stemness by Regulating PI3K/AKT/mTOR Pathway. (PubMed, Biochem Genet)
    Mechanistically, by blocking PI3K/AKT/mTOR pathway with BEZ235, the effects of SETD5 overexpression on cell viability and Nanog and Sox2 protein expression were reversed. Our results substantiated that SETD5 functioned as an oncogene by promoting cell growth and stemness in colorectal cancer cells through activating the PI3K/AKT/mTOR signaling pathway.
    Journal
    |
    SOX2 • NANOG (Nanog Homeobox) • SETD5 (SET Domain Containing 5)
    |
    SETD5 overexpression • SOX2 expression
    |
    dactolisib (RTB101)