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    GENE:

    SETD1A (SET Domain Containing 1A)

    i
    Other names: SETD1A, SET Domain Containing 1A, Histone Lysine Methyltransferase, KMT2F, KIAA0339, SET1A, Set1, Set1/Ash2 Histone Methyltransferase Complex Subunit SET1, Histone-Lysine N-Methyltransferase SETD1A, SET Domain-Containing Protein 1A, Lysine N-Methyltransferase 2F, HSET1A, SET Domain Containing 1A, NEDSID, EPEDD, Set1A, SET1
    Associations

    News

    Trials
    3ms
    Challenges in the Development of Novel Therapies for Thoracic Malignancies. (PubMed, Juntendo Med J)
    These findings highlight the need for further research into epigenetic mechanisms and their role in cancer progression. A better understanding of these processes may lead to the development of more effective, targeted therapies for the treatment of thoracic and other malignancies.
    Review • Journal • IO biomarker
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    SETD1A (SET Domain Containing 1A)
    6ms
    Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis, and Treatment. (PubMed, Curr Issues Mol Biol)
    Regional variations (e.g., Asian cohorts) and disparities in access underscore the need for standardized, cost-effective diagnostics. Future priorities include validating novel biomarkers (SBS39, miR-622) and combination therapies (PARPi with ATR inhibitors) to overcome resistance and broaden HRD's applicability across cancers.
    Review • Journal • BRCA Biomarker • PARP Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • HRD (Homologous Recombination Deficiency) • PALB2 (Partner and localizer of BRCA2) • BRCA (Breast cancer early onset) • RAD51 (RAD51 Homolog A) • RAD51C (RAD51 paralog C) • RAD51D (RAD51 paralog D) • MIR622 (MicroRNA 622) • SETD1A (SET Domain Containing 1A)
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    HRD
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    FoundationOne® CDx • Myriad myChoice® CDx
    6ms
    Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4-TAF6 axis in the cell cycle. (PubMed, Cell Death Dis)
    Notably, E2F4 supported the expression of TAF6 but not that of SETD1A, suggesting that E2F4 serves as a coregulator of SETD1A, which is involved in regulating TAF6. These results demonstrate that the non-canonical roles of SETD1A and its downstream pathways are crucial for cell cycle progression in GC.
    Journal
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    SETD1A (SET Domain Containing 1A)
    7ms
    Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K. (PubMed, Breast Cancer Res)
    SETD1A promotes breast cancer cell replication through its non-enzymatic role via cyclin K, suggesting that the SETD1A-cyclin K axis could be a potential therapeutic target in breast cancer.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • RPA3 (Replication Protein A3) • SETD1A (SET Domain Containing 1A)
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    ER positive • HER-2 negative • EGFR positive
    7ms
    Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers. (PubMed, J Transl Med)
    Collectively, our findings provide robust molecular evidence that CC and RC follow divergent oncogenic pathways, emphasizing the need for site-specific biomarker development and therapeutic targeting in colorectal cancer.
    Clinical • Journal • Tumor mutational burden
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    BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • NRAS (Neuroblastoma RAS viral oncogene homolog) • GATA2 (GATA Binding Protein 2) • EHD1 (EH Domain Containing 1) • ATP5F1E (ATP Synthase F1 Subunit Epsilon) • HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1) • SETD1A (SET Domain Containing 1A) • ACVR1B (Activin A Receptor Type 1B)
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    TP53 mutation • BRAF mutation • NRAS mutation • PIK3CA mutation
    8ms
    Retraction: Histone methyltransferase SETD1A induces epithelial-mesenchymal transition to promote invasion and metastasis through epigenetic reprogramming of snail in gastric cancer. (PubMed, Front Cell Dev Biol)
    [This retracts the article DOI: 10.3389/fcell.2021.657888.].
    Journal
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    SETD1A (SET Domain Containing 1A)
    9ms
    Effects of Zearalenone on Endoplasmic Reticulum Stress-induced Apoptosis via Global and Gene-Specific Histone Modifications and miRNA-mediated p53-signaling Pathway in HEK-293 Cells. (PubMed, Chem Biol Interact)
    miRNA array analysis showed notable and significant reductions in the expression levels of several miRNAs. The results obtained from this comprehensive study are expected to make a significant contribution to the elucidation of ZEA toxicity.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • DNMT3A (DNA methyltransferase 1) • CASP3 (Caspase 3) • DNMT1 (DNA methyltransferase 1) • CASP9 (Caspase 9) • DNMT3B (DNA Methyltransferase 3 Beta) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ATF4 (Activating Transcription Factor 4) • HAT1 (Histone Acetyltransferase 1) • SIRT1 (Sirtuin 1) • KMT5A (Lysine Methyltransferase 5A) • SETD1A (SET Domain Containing 1A) • SUV39H1 (SUV39H1 Histone Lysine Methyltransferase)
    12ms
    Potential mechanism of circKIAA1429 accelerating the progression of hepatocellular carcinoma. (PubMed, Infect Agent Cancer)
    circKIAA1429 interacts with SETD1A to inhibit the enrichment of H3K4me3 and H3K27me3 on GLIS2 or NAP1L3 promoter, thus inhibiting/promoting the expression of GLIS2/NAP1L3 and accelerating the progression of HCC.
    Journal
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    GLIS2 (GLIS Family Zinc Finger 2) • SETD1A (SET Domain Containing 1A) • VIRMA (Vir Like M6A Methyltransferase Associated)
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    dactinomycin
    12ms
    SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cells. (PubMed, Br J Cancer)
    Loss of SETD1A or EME1 drives cellular resistance to Olaparib in certain genetic contexts and may help explain why patients develop resistance to PARP inhibitors in the clinic.
    Journal • BRCA Biomarker • PARP Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • ATM (ATM serine/threonine kinase) • SETD1A (SET Domain Containing 1A)
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    Lynparza (olaparib)
    over1year
    Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA triplex generation for driving tumorigenesis. (PubMed, Nat Commun)
    The SENP5/GAU1 triplex subsequently triggers the recruitment of the methyltransferase SET1A to exon 1 of GAU1, leading to the enrichment of H3K4 trimethylation and the activation of SENP5 transcription for driving the tumorigenesis of gastric cancer in vitro and in vivo. Our study reveals a mechanism of PPIA-guided SENP5/GAU1 DNA-lncRNA triplex formation in tumorigenesis and providing a concept in the dynamics of isomerase assisted DNA-RNA hybridization.
    Journal
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    PPIA (Peptidylprolyl Isomerase A) • SETD1A (SET Domain Containing 1A)
    over1year
    Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes. (PubMed, iScience)
    Interestingly, the other prominent TKIs Nilotinib and Imatinib did not exert similar effects on muscle cell physiology. Collectively, we identified an unanticipated transcriptional mechanism underlying Sorafenib-induced cachexia. Our findings hold the potential to strategize therapy regimens to minimize chemotherapy-induced cachexia.
    Journal
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    SETD1A (SET Domain Containing 1A)
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    sorafenib • imatinib • nilotinib
    over1year
    Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation. (PubMed, J Biol Chem)
    Challenging existing models, our findings imply that MLL1F-induced leukemias arise from a dominant-negative impact on MLL1's histone methyltransferase activity. We propose targeting SETd1a in precision medicine as a new therapeutic approach for MLL1-associated leukemias.
    Journal
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    HOXA9 (Homeobox A9) • MEIS1 (Meis Homeobox 1) • SNAI2 (Snail Family Transcriptional Repressor 2) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • HOTTIP (HOXA Distal Transcript Antisense RNA) • SETD1A (SET Domain Containing 1A)
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    MLL mutation • MLL fusion